Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Journal of Nuclear Medicine

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • View or Listen to JNM Podcast
  • Visit JNM on Facebook
  • Join JNM on LinkedIn
  • Follow JNM on Twitter
  • Subscribe to our RSS feeds
Research ArticleBasic Science Investigations

Engineering and Performance (NEMA and Animal) of a Lower-Cost Higher-Resolution Animal PET/CT Scanner Using Photomultiplier-Quadrant-Sharing Detectors

Wai-Hoi Wong, Hongdi Li, Hossain Baghaei, Yuxuan Zhang, Rocio A. Ramirez, Shitao Liu, Chao Wang and Shaohui An
Journal of Nuclear Medicine November 2012, 53 (11) 1786-1793; DOI: https://doi.org/10.2967/jnumed.112.103507
Wai-Hoi Wong
Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hongdi Li
Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hossain Baghaei
Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yuxuan Zhang
Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rocio A. Ramirez
Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shitao Liu
Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chao Wang
Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shaohui An
Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • FIGURE 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 1.

    (A) Drawing of SSS technique for production of blocks: 13 crystal slabs and 12 film reflectors are sandwiched together using optical glue (a); sandwich is cut (b) into multicrystal slices (c); square block is made by gluing together 13 multicrystal slices and 12 film reflector patterns (d); and square block is ground on 4 sides with taper angle of 6° to produce heptahedron block (e). (B) Image of solid MuPET detector ring with 30,420 small LYSO crystals.

  • FIGURE 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 2.

    Axial sensitivity profile measured with 22Na point source moving along central axis of scanner.

  • FIGURE 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 3.

    Counting rate performance plots as function of total activity for mouselike (A) and ratlike (B) phantoms.

  • FIGURE 4.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 4.

    NECR as function of total activity for mouse- and ratlike phantoms.

  • FIGURE 5.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 5.

    (A) Transverse images of NEMA NU 4-2008 image-quality phantom in 5-rod region (left), uniform region (middle), and 2-chamber region (right). (B) Recovery coefficients of 5 rods as function of rod diameter. RC = recovery coefficient.

  • FIGURE 6.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 6.

    Transverse images of Micro Deluxe (A) and Ultra-Micro Hot Spot (B) phantoms. Diameter of hot rods for each rod sector is indicated in figure. The 1-mm rods were well resolved.

  • FIGURE 7.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 7.

    Nongated images of 2 healthy mice: sagittal and coronal slices of first mouse fused with CT images (A); transverse, coronal, and sagittal slices of second mouse (B) showing heart and Harderian glands. Both mice were injected with 18F-FDG. First mouse was anesthetized with ketamine–xylazine–atropine cocktail. Second mouse was anesthetized with isoflurane.

Tables

  • Figures
    • View popup
    TABLE 1

    Comparison of Specifications of MuPET with 3 Other Preclinical PET Cameras

    CategoryMuPETInveon (10, 11)NanoPET (11)LabPET8 (12)
    Crystal materialLYSOLSOLYSOLYSO/LGSO
    PhotosensorPMT (19-mm diameter)6 × 6 PSPMT256-channel PSPMTAPD
    No. of photosensors21064246,144
    No of signal channels2107686,1446,144
    Crystal size (mm)1.24 × 1.4 × 9.51.51 × 1.51 × 101.12 × 1.12 × 132 × 2 × 14
    Packing fraction95%90%92%
    No. of crystals30,42025,60037,9086,144
    No. of rings78808132
    Ring diameter (cm)16.616.118.116.2
    Axial FOV (cm)11.612.79.487.5
    Transaxial FOV (cm)10.010.012.310.0
    • LSO = lutetium oxyorthosilicate; LGSO = lutetium gadolinium oxyorthosilicate; PSPMT = position-sensitive photomultiplier tube; APD = avalanche photodiode.

    • View popup
    TABLE 2

    Radial, Tangential, and Axial Spatial Resolutions as Function of Radial Offset

    Radial offset (mm)Radial resolution (mm)Tangential resolution (mm)Axial resolution (mm)
    FWHMFWTMFWHMFWTMFWHMFWTM
    01.253.031.142.420.942.35
    21.222.921.302.420.962.57
    51.482.921.342.530.992.52
    101.523.011.392.511.002.60
    151.673.201.362.431.052.62
    201.743.471.342.451.042.63
    251.883.741.342.431.082.68
    302.084.021.362.491.122.71
    402.614.891.572.961.262.98
    • FWTM = full width at tenth maximum.

    • View popup
    TABLE 3

    Radial and Tangential Spatial Resolutions for Resolution Recovery Method as Function of Radial Offset

    Radial spatialresolution (mm)Tangential spatial resolution (mm)
    Radial offset (mm)FWHMFWTMFWHMFWTM
    00.862.020.751.68
    21.132.481.022.08
    51.112.431.02.14
    101.162.261.02.05
    151.172.41.062.16
    201.192.531.072.05
    251.262.431.062.14
    301.252.41.072.17
    401.322.541.112.38
    • FWTM = full width at tenth maximum.

PreviousNext
Back to top

In this issue

Journal of Nuclear Medicine: 53 (11)
Journal of Nuclear Medicine
Vol. 53, Issue 11
November 1, 2012
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Engineering and Performance (NEMA and Animal) of a Lower-Cost Higher-Resolution Animal PET/CT Scanner Using Photomultiplier-Quadrant-Sharing Detectors
(Your Name) has sent you a message from Journal of Nuclear Medicine
(Your Name) thought you would like to see the Journal of Nuclear Medicine web site.
Citation Tools
Engineering and Performance (NEMA and Animal) of a Lower-Cost Higher-Resolution Animal PET/CT Scanner Using Photomultiplier-Quadrant-Sharing Detectors
Wai-Hoi Wong, Hongdi Li, Hossain Baghaei, Yuxuan Zhang, Rocio A. Ramirez, Shitao Liu, Chao Wang, Shaohui An
Journal of Nuclear Medicine Nov 2012, 53 (11) 1786-1793; DOI: 10.2967/jnumed.112.103507

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Engineering and Performance (NEMA and Animal) of a Lower-Cost Higher-Resolution Animal PET/CT Scanner Using Photomultiplier-Quadrant-Sharing Detectors
Wai-Hoi Wong, Hongdi Li, Hossain Baghaei, Yuxuan Zhang, Rocio A. Ramirez, Shitao Liu, Chao Wang, Shaohui An
Journal of Nuclear Medicine Nov 2012, 53 (11) 1786-1793; DOI: 10.2967/jnumed.112.103507
Twitter logo Facebook logo LinkedIn logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSION
    • DISCLOSURE STATEMENT
    • Acknowledgments
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

  • This Month in JNM
  • PubMed
  • Google Scholar

Cited By...

  • A Prototype High-Resolution Small-Animal PET Scanner Dedicated to Mouse Brain Imaging
  • Google Scholar

More in this TOC Section

  • Synthesis and Biologic Evaluation of Novel 18F-Labeled Probes Targeting Prostate-Specific Membrane Antigen for PET of Prostate Cancer
  • Tumor-Specific Binding of Radiolabeled PEGylated GIRLRG Peptide: A Novel Agent for Targeting Cancers
  • PET/MRI of Hypoxic Atherosclerosis Using 64Cu-ATSM in a Rabbit Model
Show more Basic Science Investigations

Similar Articles

Keywords

  • small-animal PET camera
  • performance evaluation
  • Molecular imaging
  • PET instrumentation
  • MuPET
SNMMI

© 2025 SNMMI

Powered by HighWire