This Month in JNM

Imaging apoptosis: Blankenberg and Strauss provide an overview of recent advances in the molecular imaging of programmed cell death, with a focus on pathophysiology and currently available radiotracers.Page 1659

Radioembolization after PRRT: Ezziddin and colleagues report on a study of the safety of ⁹⁰Y microsphere radioembolization as salvage treatment in patients with neuroendocrine tumors after failed peptide receptor radionuclide therapy.Page 1663

Bone scans and sunitinib response: Saylor and colleagues evaluate images from a phase 2 study of sunitinib in prostate cancer to assess the significance of tyrosine kinase inhibitor–induced improvements in ^99mTc-MDP bone scans.Page 1670

Sex-dependent prognosis and SUV_max: Wainer and colleagues examine the predictive value of ¹⁸F-FDG maximum standardized uptake on PET in a surgical cohort of men and women with surgically treated early non–small cell lung cancer.Page 1676

PET in suspected NETs: Haug and colleagues investigate the use of ⁶⁸Ga-DOTATATE PET/CT as a tool for early diagnosis and reliable exclusion in patients with suspected nonlocalized neuroendocrine tumors.Page 1686

Lymphoscintigraphy and nonsentinel node metastasis: Lee and colleagues describe a new model that uses sentinel lymphoscintigraphic findings and histopathologic parameters as covariates for predicting the likelihood of nonsentinel lymph node metastases in breast cancer.Page 1693

PET index for glioma detection: Kinoshita and colleagues evaluate the utility of ¹⁸F-FDG–¹¹C-methionine PET decoupling analysis for quantitatively assessing glioma cell infiltration in nonenhancing MRI T2 hyperintense lesions.Page 1701

¹¹C-MET PET in gliomas: Singhal and colleagues compare the grading and prognostic value of ¹¹C-methionine PET with that of ¹⁸F-FDG PET and contrast-enhanced MRI in patients with gliomas.Page 1709

Image quality with PSF and TOF PET: Akamatsu and colleagues explore the effects of combined point-spread function and time-of-flight in improving ¹⁸F-FDG PET/CT images, with potential for reduced radiation or acquisition times.Page 1716

Caffeine occupancy of adenosine receptors: Elmenhorst and colleagues describe visualization and quantification of in vivo occupancy of the human cerebral A₁ adenosine receptor using ¹⁸F-CPFPX PET.Page 1723

PET and bony metastases: Chan and colleagues compare the diagnostic accuracy of ¹⁸F-FDG PET/CT with that of ¹⁸F-fluoride PET/CT in the detection of bony metastases in heightened-risk head and neck cancer patients.Page 1730

Imaging and liver radioembolization: Uliel and colleagues provide an educational overview of the anatomic, angiographic, and nuclear imaging aspects of endovascular mapping and conjoint ^99mTc-MAA hepatic perfusion imaging before radioembolization with ⁹⁰Y-loaded microspheres in hepatic malignancies.Page 1736

Immuno-PET of tissue factor: Hong and colleagues review the development of and initial studies with a PET tracer for imaging of tissue factor expression in pancreatic cancer.Page 1748

Imaging residual β-cell mass: Gialleonardo and colleagues evaluate uptake mechanisms and retention of the PET tracer ¹¹C-hydroxytryptophan in endocrine and exocrine pancreas in vitro and in vivo.Page 1755

Antitumor effects of proteasome inhibition: Altmann and colleagues study the effect of the proteasome inhibitor bortezomib on aggressive anaplastic thyroid carcinoma characterized by complete refractoriness to multimodal therapeutic approaches.Page 1764

⁶⁴Cu-labeled antibody targeting: Vāvere and colleagues detail the conjugation and biodistribution of a radiolabeled antibody that could facilitate clinical PET assessment of anti-GD2 immunotherapies and complement other imaging modalities in the staging and treatment of neuroblastoma.Page 1772

¹⁸F-FPTP cardiac PET in mice: Kim and colleagues report on initial animal studies with a radiolabeled lipophilic cationic compound with high potential as a mitochondrial voltage sensor for PET imaging.Page 1779

MuPET camera performance: Wong and colleagues describe a dedicated high-resolution, high-sensitivity, and low-cost preclinical murine PET camera and report on its conformance with NEMA standards.Page 1786

New class of Aβ tracers: Brockschnieder and colleagues report on a fruitful search for novel chemical entities that can be transformed into ¹⁸F-labeled amyloid-β tracers with favorable brain washout kinetics and low background signal for PET imaging.Page 1794

¹¹C-PHNO whole-body dosimetry: Mizrahi and colleagues measure the whole-body distribution of this promising D_2/3 agonist for PET imaging, as a function of time in adult subjects to determine the internal radiation dose.Page 1802

RADAR phantom series: Stabin and colleagues present a new generation of reference computational phantoms for internal and external dosimetry created from image-based models tied to reference masses defined by the International Commission on Radiological Protection.Page 1807

ON THE COVER

In this patient with suspected NET, an intense focus of ⁶⁸Ga-DOTATATE seen on PET, without abnormalities on CT, was histologically confirmed to be a <10-mm glucagonoma.

See page 1690.

• © 2012 by the Society of Nuclear Medicine and Molecular Imaging, Inc.