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Research ArticleClinical Investigations

Tumor 3′-Deoxy-3′-18F-Fluorothymidine (18F-FLT) Uptake by PET Correlates with Thymidine Kinase 1 Expression: Static and Kinetic Analysis of 18F-FLT PET Studies in Lung Tumors

J. Scott Brockenbrough, Timothee Souquet, Janice K. Morihara, Joshua E. Stern, Stephen E. Hawes, Janet S. Rasey, Antoine Leblond, Linda W. Wiens, Qinghua Feng, John Grierson and Hubert Vesselle
Journal of Nuclear Medicine August 2011, 52 (8) 1181-1188; DOI: https://doi.org/10.2967/jnumed.111.089482
J. Scott Brockenbrough
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Timothee Souquet
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Janice K. Morihara
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Joshua E. Stern
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Stephen E. Hawes
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Janet S. Rasey
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Antoine Leblond
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Linda W. Wiens
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Qinghua Feng
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John Grierson
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Hubert Vesselle
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Article Information

vol. 52 no. 8 1181-1188
DOI 
https://doi.org/10.2967/jnumed.111.089482
PubMed 
21764789

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication February 22, 2011
  • Accepted for publication May 4, 2011
  • Published online August 1, 2011.

Article Versions

  • previous version (July 15, 2011 - 06:29).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2011 by Society of Nuclear Medicine

Author Information

  1. J. Scott Brockenbrough1,
  2. Timothee Souquet1,
  3. Janice K. Morihara2,
  4. Joshua E. Stern2,
  5. Stephen E. Hawes3,
  6. Janet S. Rasey4,
  7. Antoine Leblond1,
  8. Linda W. Wiens1,
  9. Qinghua Feng2,
  10. John Grierson1 and
  11. Hubert Vesselle1
  1. 1Division of Nuclear Medicine, Department of Radiology, University of Washington School of Medicine, Seattle, Washington
  2. 2Department of Pathology, University of Washington School of Medicine, Seattle, Washington
  3. 3Department of Epidemiology, School of Public Health and Community Medicine, University of Washington School of Medicine, Seattle, Washington; and
  4. 4Department of Radiation Oncology, University of Washington School of Medicine, Seattle, Washington
  1. For correspondence or reprints contact: Hubert Vesselle, Division of Nuclear Medicine, Department of Radiology, University of Washington Medical Center, P.O. Box 357115, 1959 NE Pacific St., Seattle, WA 98195-7115. E-mail: vesselle{at}u.washington.edu
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  • Early reduction in tumour [18F]fluorothymidine (FLT) uptake in patients with non-small cell lung cancer (NSCLC) treated with radiotherapy alone
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Journal of Nuclear Medicine: 52 (8)
Journal of Nuclear Medicine
Vol. 52, Issue 8
August 1, 2011
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Tumor 3′-Deoxy-3′-18F-Fluorothymidine (18F-FLT) Uptake by PET Correlates with Thymidine Kinase 1 Expression: Static and Kinetic Analysis of 18F-FLT PET Studies in Lung Tumors
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Tumor 3′-Deoxy-3′-18F-Fluorothymidine (18F-FLT) Uptake by PET Correlates with Thymidine Kinase 1 Expression: Static and Kinetic Analysis of 18F-FLT PET Studies in Lung Tumors
J. Scott Brockenbrough, Timothee Souquet, Janice K. Morihara, Joshua E. Stern, Stephen E. Hawes, Janet S. Rasey, Antoine Leblond, Linda W. Wiens, Qinghua Feng, John Grierson, Hubert Vesselle
Journal of Nuclear Medicine Aug 2011, 52 (8) 1181-1188; DOI: 10.2967/jnumed.111.089482

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Tumor 3′-Deoxy-3′-18F-Fluorothymidine (18F-FLT) Uptake by PET Correlates with Thymidine Kinase 1 Expression: Static and Kinetic Analysis of 18F-FLT PET Studies in Lung Tumors
J. Scott Brockenbrough, Timothee Souquet, Janice K. Morihara, Joshua E. Stern, Stephen E. Hawes, Janet S. Rasey, Antoine Leblond, Linda W. Wiens, Qinghua Feng, John Grierson, Hubert Vesselle
Journal of Nuclear Medicine Aug 2011, 52 (8) 1181-1188; DOI: 10.2967/jnumed.111.089482
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  • FLT PET/CT imaging of metastatic prostate cancer patients treated with pTVG-HP DNA vaccine and pembrolizumab
  • Variability of Proliferation and Diffusion in Different Lung Cancer Models as Measured by 3'-Deoxy-3'-18F-Fluorothymidine PET and Diffusion-Weighted MR Imaging
  • Prognostic and Therapeutic Impact of Argininosuccinate Synthetase 1 Control in Bladder Cancer as Monitored Longitudinally by PET Imaging
  • PET Imaging of Proliferation with Pyrimidines
  • Assessment of Cellular Proliferation in Tumors by PET Using 18F-ISO-1
  • In Vivo Imaging of Cell Proliferation Enables the Detection of the Extent of Experimental Rheumatoid Arthritis by 3'-Deoxy-3'-18F-Fluorothymidine and Small-Animal PET
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