Effects of Administration Route, Dietary Condition, and Blood Glucose Level on Kinetics and Uptake of ¹⁸F-FDG in Mice

Representative examples of biodistribution of ¹⁸F-FDG at different times in nonfasting mice after intravenous (A) and intraperitoneal (B) injection. Small-animal PET images are fused with CT images for anatomic localization of structures such as myocardium, lung, liver, gastrointestinal tract, and urinary bladder (shown in coronal view) and brain (shown in transaxial view). Color bars are scaled differently for coronal and transaxial views.

Mean SUV (A), K_i (B), and MRGlu (C) of brain, myocardium, and skeletal muscle obtained from nonfasting and fasting animals after intravenous (IV) or intraperitoneal (IP) injection of ¹⁸F-FDG. Error bars represent 1 SD. P values were calculated using Bonferroni post hoc test (⁺P < 0.05, ^#P < 0.01, *P < 0.001 vs. nonfasting condition using same administration route).