Article Figures & Data
Figures
- FIGURE 1.
Immediately after and at 48 h after sonication, EB extravasation was measured in brain tissue. (A) EB in sonicated and contralateral regions of normal brain. (B) Disruption–to–nondisruption ratio of normal brain. (C) EB in tumor tissue and in neighboring normal brain regions with and without sonication. Immediately after sonication, EB in brain tumor with sonication was significantly higher than that in brain tumor without sonication. No significant difference was found between them at 48 h after sonication. (D) Tumor–to–ipsilateral brain EB ratio of brain tumor. *P < 0.05. ***P < 0.001.
- FIGURE 2.
SPECT/CT images of F98 glioma–bearing Fischer 344 rats at 15, 30, 45, and 60 min after intravenous injection of 74 MBq (2 mCi) of 99mTc-DTPA in axial (A) and coronal (B) views. Right brain, tumor with sonication; left brain, tumor without sonication. Animals were under isoflurane anesthesia, and image acquisition time was 15 min.
- FIGURE 3.
Pharmacokinetics of 99mTc-DTPA for normal Fischer 344 rats was determined by SPECT/CT. (A) Time–activity curves of 99mTc-DTPA in sonicated and contralateral brains of Fischer 344 rats were derived from dynamic SPECT/CT images after intravenous injection; these were measured with and without BBB-D. (B) Disruption-to-nondisruption ratios of 99mTc-DTPA in brains. *P < 0.05. **P < 0.01.
- FIGURE 4.
Pharmacokinetics of 99mTc-DTPA for F98 glioma–bearing rats determined by SPECT/CT. (A) Time–activity curves of 99mTc-DTPA in tumors and in ipsilateral brains of F98 glioma–bearing rats were derived from dynamic SPECT/CT images after intravenous injection; these were measured with and without BBB-D. (B) Tumor–to–ipsilateral brain ratio for 99mTc-DTPA. *P < 0.05.
- FIGURE 5.
Numbers of apoptotic cells (mean ± SEM) in sonicated tumors and control tumors from histologic observations using TUNEL-stained sections.
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