Article Figures & Data
Figures
- FIGURE 1.
Comparison of neurologic deficit scores (0 = normal, 100 = worst score) between hMSC-treated monkeys and controls. No significant difference was found between hMSC treatment groups and corresponding controls before treatment (week 0). Significantly better scores were observed in both early treatment group (P < 0.05) and late treatment group (P < 0.01) when data were analyzed with 2-way ANOVA with 1 repeated factor of posttreatment week.
- FIGURE 2.
Serial PET images demonstrating metabolism recovery after ICH establishment. Four typical cases that underwent early (at week 1 after modeling, upper 2 rows) or late (at week 4, lower 2 rows) treatment were shown as control and hMSC-treated monkey brains compared one by one. Pink arrow points to intense 18F-FDG uptake at hematoma region in early hMSC-treated monkey, and orange arrow shows higher 18F-FDG accumulation at ipsilateral basal ganglia 1 wk after hMSC injection as early response. Scale was set according to percentage of maximum signal intensity.
- FIGURE 3.
Demonstration of setting regions of interest over serial PET images (A–D) and metabolic recovery (shown as mean ± SD of uptake ratio to contralateral side) according to week after ICH establishment. Adjacent cortex and basal ganglia were evaluated separately (E and F, respectively), and lines connecting means show trend and vertical lines of SD for variability in different groups. Red and orange arrows show time of early and late treatment, respectively.
- FIGURE 4.
Hematoxylin and eosin staining (×40) of ICH remnants (A: control; B: hMSC-treated) and comparison of MVD at ICH remnants between early treatment group and corresponding control (C) and between late treatment group and its control (D).
Tables
Category Score Consciousness Normal, consistently alert, strongly aggressive, escape-prone 0 Conscious but clouded, strongly aggressive 2 Conscious, poorly aggressive 4 Conscious, light opposition, escape-prone 6 Conscious but clouded and accepting 8 Drowsiness, aroused with stimulation 10 Lethargic, eyes open by strong stimulation 16 Stuporous, aroused with persistent stimulation 20 Light coma, reflex movement only 24 Deep coma, no movement 28 Skeletal muscle coordination Normal, walks normally 0 Light, transient abnormality in motor coordination 2 Minimal ataxia, walks with some impairment of gait 4 Ataxia but able to climb the cage 6 Walks with compelling stimulation but has difficulty in climbing the cage 8 Stands spontaneously, falls within a few steps 10 Sits, just able to circle with compelling stimulation 12 Sits or prostrate, cannot stand or sit for long duration, with response to compelling stimulation 14 Posed lateral or dorsal recumbency, with response to compelling stimulation 16 No movement, almost with no response to compelling stimulation 18 Sensory system Facial sensation (ipsi-/contralateral, 0–3 × 2) Concerted reaction to compelling stimulation (aggression, threaten, escape-prone, expressing goodwill) 0/0 Decrease in concerted reaction to compelling stimulation (obvious decreases in aggressive or threatening expressions) 1/1 Decrease in concerted reaction to compelling stimulation (obvious decreases in expressing goodwill) 2/2 Absent, does not react to compelling stimulation in any area of face 3/3 Pinna reflex (ipsi-/contralateral, 0–3 × 2) Twitches ear normally 0/0 Slight reduction in ear twitching, twitches ear by sonic stimulation 1/1 Obvious reduction in ear twitching, no ear twitching by sonic stimulation 2/2 Absent, does not move ear by contact stimulation 3/3 Pain reflex (lower limb, ipsi-/contralateral, 0–5 × 2) Strong, quick, complete withdrawal by contact stimulation 0/0 Comparatively quick withdrawal by contact stimulation 1/1 Comparatively slow withdrawal by contact stimulation 2/2 Weak, slow, incomplete, or inconsistent withdrawal by contact stimulation 3/3 Very weak, slow withdrawal by contact stimulation 4/4 Absent, no withdrawal by contact stimulation 5/5 Motor system Hand (ipsi-/contralateral, 0–4 × 2) Normal 0/0 Light dyskinesia (slow velocity, poor strength, and parasexuality) 1/1 Reduced strength or skill (comparatively obvious dyskinesia) 2/2 Obvious dyskinesia (very slow velocity, very poor strength, and parasexuality) 3/3 Paralysis or useless 4/4 Leg (ipsi-/contralateral, 0–6 × 2) Normal 0/0 Light dyskinesia (slow velocity, poor strength, and parasexuality) 1/1 Raises with flexion of knee (comparatively obvious dyskinesia) 2/2 Obvious dyskinesia (very slow velocity, very poor strength, and parasexuality) 3/3 Can move, but not against gravity 4/4 Almost cannot move 5/5 Paralysis or useless 6/6 Upper-limb tone (ipsi-/contralateral, 0–3 × 2) Normal 0/0 Lightly spastic or flaccid (occasionally raised fingers when grasping) 1/1 Relatively spastic or flaccid (continued to raise fingers when grasping) 2/2 Obviously spastic or flaccid 3/3 Lower-limb tone (ipsi-/contralateral, 0–3 × 2) Normal 0/0 Lightly spastic or flaccid (occasionally raised toes when grasping) 1/1 Relatively spastic or flaccid (continued to raise toes when grasping) 2/2 Obviously spastic or flaccid 3/3
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