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Journal of Nuclear Medicine

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OtherBASIC SCIENCE INVESTIGATIONS

Design and Optimization of Coin-Shaped Microreactor Chips for PET Radiopharmaceutical Synthesis

Arkadij M. Elizarov, R. Michael van Dam, Young Shik Shin, Hartmuth C. Kolb, Henry C. Padgett, David Stout, Jenny Shu, Jiang Huang, Antoine Daridon and James R. Heath
Journal of Nuclear Medicine February 2010, 51 (2) 282-287; DOI: https://doi.org/10.2967/jnumed.109.065946
Arkadij M. Elizarov
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R. Michael van Dam
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Young Shik Shin
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Hartmuth C. Kolb
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Henry C. Padgett
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David Stout
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Jenny Shu
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Jiang Huang
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Antoine Daridon
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James R. Heath
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  • SCHEME 1. 
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    SCHEME 1. 

    Radiosynthesis of 18F-FDG (1).

  • FIGURE 1. 
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    FIGURE 1. 

    Schematic of coin-shaped reactor designed for maximum heat and mass transfer, efficient evaporation, and convenient placement of ports.

  • FIGURE 2. 
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    FIGURE 2. 

    Complete design of coin-shaped reactor chip. C1 is ion exchange column, and C2 is product purification column, both located off-chip. Reagents are introduced or removed through indicated channels, via open valves 1–10. Radiator vent is shown in yellow. Light green square outlines physical boundaries of chip. K222 = Kryptofix2.2.2.

  • FIGURE 3. 
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    FIGURE 3. 

    (A) Photograph of chip with off-chip ion exchange column (C1) controlled by on-chip valves. (B) Photograph of chip designed for coupling with off-chip ion exchange column operated by off-chip loop valve. Chip is filled with dyes for visualization. Fluid network is shown in green, valves in red, and vent in yellow.

  • FIGURE 4. 
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    FIGURE 4. 

    PET image of tumor-bearing mouse.

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Journal of Nuclear Medicine: 51 (2)
Journal of Nuclear Medicine
Vol. 51, Issue 2
February 2010
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Design and Optimization of Coin-Shaped Microreactor Chips for PET Radiopharmaceutical Synthesis
Arkadij M. Elizarov, R. Michael van Dam, Young Shik Shin, Hartmuth C. Kolb, Henry C. Padgett, David Stout, Jenny Shu, Jiang Huang, Antoine Daridon, James R. Heath
Journal of Nuclear Medicine Feb 2010, 51 (2) 282-287; DOI: 10.2967/jnumed.109.065946

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Design and Optimization of Coin-Shaped Microreactor Chips for PET Radiopharmaceutical Synthesis
Arkadij M. Elizarov, R. Michael van Dam, Young Shik Shin, Hartmuth C. Kolb, Henry C. Padgett, David Stout, Jenny Shu, Jiang Huang, Antoine Daridon, James R. Heath
Journal of Nuclear Medicine Feb 2010, 51 (2) 282-287; DOI: 10.2967/jnumed.109.065946
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