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Research ArticleBasic Science Investigation

Preclinical Evaluation of 18F-JNJ41510417 as a Radioligand for PET Imaging of Phosphodiesterase-10A in the Brain

Sofie Celen, Michel Koole, Meri De Angelis, Ivan Sannen, Satish K. Chitneni, Jesus Alcazar, Stefanie Dedeurwaerdere, Dieder Moechars, Mark Schmidt, Alfons Verbruggen, Xavier Langlois, Koen Van Laere, José Ignacio Andrés and Guy Bormans
Journal of Nuclear Medicine October 2010, 51 (10) 1584-1591; DOI: https://doi.org/10.2967/jnumed.110.077040
Sofie Celen
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Michel Koole
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Meri De Angelis
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Ivan Sannen
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Satish K. Chitneni
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Jesus Alcazar
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Stefanie Dedeurwaerdere
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Dieder Moechars
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Mark Schmidt
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Alfons Verbruggen
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Xavier Langlois
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Koen Van Laere
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José Ignacio Andrés
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Guy Bormans
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Article Information

vol. 51 no. 10 1584-1591
DOI 
https://doi.org/10.2967/jnumed.110.077040
PubMed 
20847170

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication March 9, 2010
  • Accepted for publication July 14, 2010
  • Published online October 1, 2010.

Article Versions

  • previous version (September 16, 2010 - 08:32).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2010 by Society of Nuclear Medicine

Author Information

  1. Sofie Celen1,
  2. Michel Koole2,
  3. Meri De Angelis3,
  4. Ivan Sannen1,
  5. Satish K. Chitneni1,
  6. Jesus Alcazar3,
  7. Stefanie Dedeurwaerdere4,
  8. Dieder Moechars4,
  9. Mark Schmidt4,
  10. Alfons Verbruggen1,
  11. Xavier Langlois4,
  12. Koen Van Laere2,
  13. José Ignacio Andrés3 and
  14. Guy Bormans1
  1. 1Laboratory for Radiopharmacy, Faculty of Pharmaceutical Sciences, K.U. Leuven, Leuven, Belgium
  2. 2Department of Nuclear Medicine, K.U. Leuven, Leuven, Belgium
  3. 3Johnson and Johnson Pharmaceutical Research and Development, Toledo, Spain; and
  4. 4Johnson and Johnson Pharmaceutical Research and Development, Beerse, Belgium
  1. For correspondence contact: Guy Bormans, Laboratory for Radiopharmacy, Faculty of Pharmaceutical Sciences, K.U. Leuven, Herestraat 49, B-3000 Leuven, Belgium. E-mail: guy.bormans{at}pharm.kuleuven.be
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Journal of Nuclear Medicine: 51 (10)
Journal of Nuclear Medicine
Vol. 51, Issue 10
October 1, 2010
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Preclinical Evaluation of 18F-JNJ41510417 as a Radioligand for PET Imaging of Phosphodiesterase-10A in the Brain
Sofie Celen, Michel Koole, Meri De Angelis, Ivan Sannen, Satish K. Chitneni, Jesus Alcazar, Stefanie Dedeurwaerdere, Dieder Moechars, Mark Schmidt, Alfons Verbruggen, Xavier Langlois, Koen Van Laere, José Ignacio Andrés, Guy Bormans
Journal of Nuclear Medicine Oct 2010, 51 (10) 1584-1591; DOI: 10.2967/jnumed.110.077040

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Preclinical Evaluation of 18F-JNJ41510417 as a Radioligand for PET Imaging of Phosphodiesterase-10A in the Brain
Sofie Celen, Michel Koole, Meri De Angelis, Ivan Sannen, Satish K. Chitneni, Jesus Alcazar, Stefanie Dedeurwaerdere, Dieder Moechars, Mark Schmidt, Alfons Verbruggen, Xavier Langlois, Koen Van Laere, José Ignacio Andrés, Guy Bormans
Journal of Nuclear Medicine Oct 2010, 51 (10) 1584-1591; DOI: 10.2967/jnumed.110.077040
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  • Change in PDE10 across early Huntington disease assessed by [18F]MNI-659 and PET imaging
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