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Research ArticleCLINICAL INVESTIGATIONS

Physiologic Thymic Uptake of 18F-FDG in Children and Young Adults: A PET/CT Evaluation of Incidence, Patterns, and Relationship to Treatment

Jacqueline Jerushalmi, Alex Frenkel, Rachel Bar-Shalom, Jabour Khoury and Ora Israel
Journal of Nuclear Medicine June 2009, 50 (6) 849-853; DOI: https://doi.org/10.2967/jnumed.108.058586
Jacqueline Jerushalmi
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Alex Frenkel
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Rachel Bar-Shalom
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Jabour Khoury
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Ora Israel
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  • FIGURE 1. 
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    FIGURE 1. 

    Physiologic 18F-FDG uptake in thymus in 34-y-old female patient with Hodgkin disease assessed during routine follow-up 13 mo after completion of chemotherapy. Note focal midline pattern of uptake with extension to right (arrow), with SUVmax of 3.8.

  • FIGURE 2. 
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    FIGURE 2. 

    Patterns of physiologic 18F-FDG uptake in thymus: classic inverted V triangular (A), unilateral right extension (B), and focal midline (C).

Tables

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    TABLE 1

    Incidence and Age-Related Distribution of 18F-FDG Uptake in Thymus in 559 PET/CT Studies

    T+/total no. in this age groupT+ in this age group/all T+
    Age (y)PatientsStudiesPatientsStudies
    0–109/12 (75)28/35 (80)9/44 (20)28/137 (20)
    11–2014/33 (42)58/114 (51)14/44 (32)58/137 (42)
    21–3013/56 (23)34/193 (18)13/44 (30)34/137 (25)
    31–408/69 (12)17/217 (8)8/44 (18)17/137 (13)
    Total44/170* (26)137/559 (25)
    • ↵* 10 patients are included in 2 different age groups because follow-up studies were performed during different decades of age.

    • Data in parentheses are percentage of patients or studies.

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    TABLE 2

    Physiologic 18F-FDG Uptake in Thymus in Relationship to Treatment Administration

    T+/total number
    Time of studyPatients (n = 44)Studies (n = 137)
    Before treatment11/66 (17)11/66 (17)
    During treatment5/78 (6)5/78 (6)
    End of treatment5/63 (8)5/63 (8)
    FU < 6 mo20/42 (48)21/52 (40)
    FU 6–11 mo18/58 (31)24/72 (33)
    FU 12–24 mo24/79 (30)44/128 (34)
    FU > 24 mo15/54 (28)27/100 (27)
    • FU = follow-up.

    • Data in parentheses are percentage of patients or studies.

    • View popup
    TABLE 3

    Frequency of T+ Studies According to Patient Age and Treatment Status

    Age group (y)
    Time of study0–1011–2021–3031–40Total
    Baseline3/3 (100)2/8 (25)4/19 (21)2/36 (6)11/66 (17)
    During treatment2/5 (40)1/16 (6)1/26 (4)1/31 (3)5/78 (6)
    End of treatment2/4 (50)3/13 (23)0/23 (0)0/23 (0)5/63 (8)
    FU < 6 mo4/4 (100)7/11 (64)5/17 (29)5/20 (25)21/52 (40)
    FU 6–11 mo7/9 (78)8/15 (53)6/23 (26)3/25 (12)24/72 (33)
    FU 12–24 mo7/7 (100)23/32 (72)11/41 (27)3/48 (6)44/128 (34)
    FU > 24 mo3/3 (100)14/19 (74)7/44 (16)3/34 (9)27/100 (27)
    Total28/35 (80)58/114 (51)34/193 (18)17/217 (8)137/559 (25)
    • FU = follow-up.

    • Data in parentheses are percentage of patients.

    • View popup
    TABLE 4

    Intensity of Physiologic 18F-FDG Uptake in Thymus Measured by SUVmax in Relationship to Treatment Administration

    Time of study (no. of patients)Mean ± SDRange
    Before treatment (n = 10)3.8 ± 0.52.8–4.7
    During treatment (n = 5)2.8 ± 0.72–3.7
    End of treatment (n = 5)2.7 ± 0.62–3.3
    FU < 6 mo (n = 18)3.8 ± 1.42–7
    FU 6–11 mo (n = 24)3.7 ± 1.31.2–7.3
    FU 12–24 mo (n = 44)3.9 ± 1.21.8–5.8
    FU > 24 mo (n = 27)3.8 ± 1.31.9–7
    • FU = follow-up.

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Journal of Nuclear Medicine: 50 (6)
Journal of Nuclear Medicine
Vol. 50, Issue 6
June 2009
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Physiologic Thymic Uptake of 18F-FDG in Children and Young Adults: A PET/CT Evaluation of Incidence, Patterns, and Relationship to Treatment
Jacqueline Jerushalmi, Alex Frenkel, Rachel Bar-Shalom, Jabour Khoury, Ora Israel
Journal of Nuclear Medicine Jun 2009, 50 (6) 849-853; DOI: 10.2967/jnumed.108.058586

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Physiologic Thymic Uptake of 18F-FDG in Children and Young Adults: A PET/CT Evaluation of Incidence, Patterns, and Relationship to Treatment
Jacqueline Jerushalmi, Alex Frenkel, Rachel Bar-Shalom, Jabour Khoury, Ora Israel
Journal of Nuclear Medicine Jun 2009, 50 (6) 849-853; DOI: 10.2967/jnumed.108.058586
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