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Peptide receptor imaging is based on agonist-induced internalization of peptide receptors in tumor cells. Compared with control rats (left), rats sacrificed at 2.5 min (middle) and 1 h (right) after TATE injection showed internalization of sst2 in AR24J tumors on R2-88 immunohistochemistry. This molecular process is likely responsible for the uptake of sst2 radioligands seen in vivo in sst2-expressing tumors.
See page 936.