Article Figures & Data
Figures
- FIGURE 1.
In vivo micro-SPECT/micro-CT transverse (A) and sagittal (B) zoomed and masked images of the 5 study groups. MPI uptake in atherosclerotic aortic lesions was identified noninvasively in arch and abdominal aorta by micro-SPECT aided by micro-CT; aortic arch calcification was detected by micro-CT. Ch = high-cholesterol-fed.
- FIGURE 2.
MPI uptake in aorta by ex vivo imaging (A) and quantitative estimates of tracer uptake (B) in the 5 study groups. Ex vivo imaging reveals background activity in wild-type mice. Uptake in transgenic mice is further enhanced by high-cholesterol diet (Ch). Uptake is most prominently seen in aortic arch. Bar graphs show quantitative 99mTc-MPI uptake, represented as mean (±SD) %ID/g, in each part of aorta in the various animal groups. MPI uptake in B corresponds to ex vivo images in A.
- FIGURE 3.
Histopathologic and immunohistochemical characterization of atherosclerotic lesions in the 5 study groups. Magnification is ×20. Ch = high-cholesterol-fed.
- FIGURE 4.
Quantitative histologic analysis of MMP-2 (A), MMP-9 (B), and macrophage (C) expressions in aortic tissue specimens from the 5 study groups and their correlation with %ID/g uptake. Percent positive areas are presented as mean ± SD in each group. When 1 outlier observation from immunohistochemical staining for macrophages was removed (C), correlation between %ID/g uptake became highly significant. Ch = high-cholesterol-fed.
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