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OtherBASIC SCIENCE INVESTIGATIONS

Initial Characterization of an 18F-Labeled Myocardial Perfusion Tracer

Marc C. Huisman, Takahiro Higuchi, Sybille Reder, Stephan G. Nekolla, Thorsten Poethko, Hans-Jürgen Wester, Sibylle I. Ziegler, David S. Casebier, Simon P. Robinson and Markus Schwaiger
Journal of Nuclear Medicine April 2008, 49 (4) 630-636; DOI: https://doi.org/10.2967/jnumed.107.044727
Marc C. Huisman
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Takahiro Higuchi
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Sybille Reder
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Stephan G. Nekolla
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Thorsten Poethko
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Hans-Jürgen Wester
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Sibylle I. Ziegler
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David S. Casebier
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Simon P. Robinson
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Markus Schwaiger
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Article Information

vol. 49 no. 4 630-636
DOI 
https://doi.org/10.2967/jnumed.107.044727
PubMed 
18344426

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication June 28, 2007
  • Accepted for publication December 4, 2007
  • Published online March 28, 2008.

Article Versions

  • previous version (March 14, 2008 - 11:49).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2008 by Society of Nuclear Medicine

Author Information

  1. Marc C. Huisman 1 ,
  2. Takahiro Higuchi 1 ,
  3. Sybille Reder 1 ,
  4. Stephan G. Nekolla 1 ,
  5. Thorsten Poethko 1 ,
  6. Hans-Jürgen Wester 1 ,
  7. Sibylle I. Ziegler 1 ,
  8. David S. Casebier 2 ,
  9. Simon P. Robinson 2 and
  10. Markus Schwaiger 1
  1. 1Department of Nuclear Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany; and 2Department of Discovery Chemistry and Department of Discovery Biology, Bristol Myers Squibb Medical Imaging, North Billerica, Massachusetts
  1. For correspondence contact: Markus Schwaiger, MD, Nuklearmedizinische Klinik der Technischen Universität München, Ismaninger Strasse 22, 81675 Munich, Germany. E-mail: markus.schwaiger{at}tum.de
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Journal of Nuclear Medicine: 49 (4)
Journal of Nuclear Medicine
Vol. 49, Issue 4
April 2008
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Initial Characterization of an 18F-Labeled Myocardial Perfusion Tracer
Marc C. Huisman, Takahiro Higuchi, Sybille Reder, Stephan G. Nekolla, Thorsten Poethko, Hans-Jürgen Wester, Sibylle I. Ziegler, David S. Casebier, Simon P. Robinson, Markus Schwaiger
Journal of Nuclear Medicine Apr 2008, 49 (4) 630-636; DOI: 10.2967/jnumed.107.044727

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Initial Characterization of an 18F-Labeled Myocardial Perfusion Tracer
Marc C. Huisman, Takahiro Higuchi, Sybille Reder, Stephan G. Nekolla, Thorsten Poethko, Hans-Jürgen Wester, Sibylle I. Ziegler, David S. Casebier, Simon P. Robinson, Markus Schwaiger
Journal of Nuclear Medicine Apr 2008, 49 (4) 630-636; DOI: 10.2967/jnumed.107.044727
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Cited By...

  • Rest/Stress Myocardial Perfusion Imaging by Positron Emission Tomography with 18F-Flurpiridaz: A Feasibility Study in Mice
  • Diagnostic Performance of PET Versus SPECT Myocardial Perfusion Imaging in Patients with Smaller Left Ventricles: A Substudy of the 18F-Flurpiridaz Phase III Clinical Trial
  • Phase-III Clinical Trial of Fluorine-18 Flurpiridaz Positron Emission Tomography for Evaluation of Coronary Artery Disease
  • Stability of Distribution of F18 Flurpiridaz After Transient Coronary Occlusion in Pigs
  • Quantitative Assessment of Coronary Microvascular Function: Dynamic Single-Photon Emission Computed Tomography, Positron Emission Tomography, Ultrasound, Computed Tomography, and Magnetic Resonance Imaging
  • Integration of Quantitative Positron Emission Tomography Absolute Myocardial Blood Flow Measurements in the Clinical Management of Coronary Artery Disease
  • Comparison of 18F-Labeled Fluoroalkylphosphonium Cations with 13N-NH3 for PET Myocardial Perfusion Imaging
  • Absolute Quantitation of Myocardial Blood Flow in Human Subjects With or Without Myocardial Ischemia Using Dynamic Flurpiridaz F 18 PET
  • Novel PET Probes 18F-BCPP-EF and 18F-BCPP-BF for Mitochondrial Complex I: A PET Study in Comparison with 18F-BMS-747158-02 in Rat Brain
  • Small-Animal PET Imaging of Isolated Perfused Rat Heart
  • Assessment of the 18F-Labeled PET Tracer LMI1195 for Imaging Norepinephrine Handling in Rat Hearts
  • Phase II Safety and Clinical Comparison With Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging for Detection of Coronary Artery Disease: Flurpiridaz F 18 Positron Emission Tomography
  • Evaluation of a Mitochondrial Voltage Sensor, (18F-Fluoropentyl)Triphenylphosphonium Cation, in a Rat Myocardial Infarction Model
  • Synthesis and Preliminary Evaluation of 18F-Labeled Pyridaben Analogues for Myocardial Perfusion Imaging with PET
  • Phase I, First-in-Human Study of BMS747158, a Novel 18F-Labeled Tracer for Myocardial Perfusion PET: Dosimetry, Biodistribution, Safety, and Imaging Characteristics After a Single Injection at Rest
  • Stable Delineation of the Ischemic Area by the PET Perfusion Tracer 18F-Fluorobenzyl Triphenyl Phosphonium After Transient Coronary Occlusion
  • Simplified Quantification of Myocardial Flow Reserve with flurpiridaz F 18: Validation with Microspheres in a Pig Model
  • Cardiac Positron Emission Tomography
  • Absolute Figures Are Better Than Percentages
  • Comparison of Positron Emission Tomography Measurement of Adenosine-Stimulated Absolute Myocardial Blood Flow Versus Relative Myocardial Tracer Content for Physiological Assessment of Coronary Artery Stenosis Severity and Location
  • Evaluation of the Novel Myocardial Perfusion Positron-Emission Tomography Tracer 18F-BMS-747158-02: Comparison to 13N-Ammonia and Validation With Microspheres in a Pig Model
  • A Novel 18F-Labeled Tracer for the Quantification of Myocardial Blood Flow and Infarct Size With Positron-Emission Tomography: Another Way to Avoid the Need of an On-Site Cyclotron
  • Evaluation of a Novel 18F-Labeled Positron-Emission Tomography Perfusion Tracer for the Assessment of Myocardial Infarct Size in Rats
  • A New 18F-Labeled Myocardial PET Tracer: Myocardial Uptake After Permanent and Transient Coronary Occlusion in Rats
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