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OtherBASIC SCIENCE INVESTIGATIONS

A Method to Correct for Radioactivity in Large Vessels That Overlap the Spine in Imaging-Based Marrow Dosimetry of Lumbar Vertebrae

Ruby F. Meredith, Sui Shen, Andres Forero and Albert LoBuglio
Journal of Nuclear Medicine February 2008, 49 (2) 279-284; DOI: https://doi.org/10.2967/jnumed.107.045021
Ruby F. Meredith
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Sui Shen
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Andres Forero
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Albert LoBuglio
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  • FIGURE 1. 
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    FIGURE 1. 

    CT image of lumbar ROI illustrating relative position and depth of aorta and IVC compared with spine.

  • FIGURE 2. 
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    FIGURE 2. 

    Comparison of depth of aorta, IVC, and vertebra from posterior surface at L4. Each line represents data from an individual patient.

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    TABLE 1

    Cross-Sectional Area of Aorta and IVC Measured at L2 and L4 Levels

    ParameterL2 aortic area (cm2)L4 aortic area (cm2)L2 IVC area (cm2)L4 IVC area (cm2)
    Mean2.31.73.42.5
    Range1.2–3.30.8–2.81.7–6.41.3–3.8
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    TABLE 2

    Aortic and IVC Volumes from L2–L4: Comparison with Trabecular Lumbar Marrow Volume

    ParameterL2–L4 length (cm)Aortic volume (cm3)IVC volume (cm3)Aortic + IVC volume (cm3)Marrow volume (cm3)*
    Mean9.919.331.250.567
    Range7–11.210.1–33.114.9–68.525.0–94.046–102
    • ↵* Trabecular marrow volume previously reported (18).

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    TABLE 3

    Comparison of Depth (cm) of Mid Aorta, IVC, and Vertebral Body from Posterior Surface at L2 and L4

    Aorta at…IVC at…Vertebra at…
    ParameterL2L4L2L4L2L4
    Mean11.712.811.712.39.09.8
    Range90.2–20.27–18.78.5–18.67.5–18.96.4–12.66.8–16.3
    • View popup
    TABLE 4

    Impact of Effective T1/2 and Cumulated Blood Activity Concentration on L2–L4 Imaging-Based Marrow Dose

    Whole-body T1/2 (h)Blood T1/2, 1 compartment (h)Blood cumulated activity (GBq-s/mL)Change in marrow dose (%)
    GroupRadionuclideMeanRangeMeanRangeMeanRangeMeanRange
    1 (n = 5)111In-B9E9 pretarget3326–401610–220.270.13–0.4031–7
    2 (n = 8)111In-ibritumomab tiuxetan5549–613130–354.32.0–6.9179–24
    3 (n = 4)131I-HuCC49ΔCh23832–422019–258.96.7–10.82415–28
    4 (n = 9)111In-CC496156–645438–703.31.5–5.1156–26
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Journal of Nuclear Medicine: 49 (2)
Journal of Nuclear Medicine
Vol. 49, Issue 2
February 2008
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A Method to Correct for Radioactivity in Large Vessels That Overlap the Spine in Imaging-Based Marrow Dosimetry of Lumbar Vertebrae
Ruby F. Meredith, Sui Shen, Andres Forero, Albert LoBuglio
Journal of Nuclear Medicine Feb 2008, 49 (2) 279-284; DOI: 10.2967/jnumed.107.045021

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A Method to Correct for Radioactivity in Large Vessels That Overlap the Spine in Imaging-Based Marrow Dosimetry of Lumbar Vertebrae
Ruby F. Meredith, Sui Shen, Andres Forero, Albert LoBuglio
Journal of Nuclear Medicine Feb 2008, 49 (2) 279-284; DOI: 10.2967/jnumed.107.045021
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