Combining optical and nuclear imaging: Culver and colleagues provide a molecular imaging focus on the current status of multimodality applications fusing PET or SPECT with optical techniques in small-animal and clinical studies.
Page 169
Sudden arrhythmic cardiac death: Travin assesses the role for radionuclide imaging approaches in prediction and prevention of death resulting from ventricular arrhythmia, including the potential for management benefits in patients with implantable cardioverter defibrillators.
Page 173
Resolving 123I-ADAM neuroimaging questions: Slifstein reviews past discrepancies in modeling approaches for neuroimaging with the serotonin transporter radioligand 123I-ADAM and previews a related article in this issue of JNM.
Page 176
PET and CT accuracy in pulmonary nodules: Fletcher and colleagues report on a multiinstitutional study comparing the ability of PET and CT imaging to characterize solitary lung nodules in a population of military veterans.
Page 179
Dual-tracer PET/CT in lung nodules: Tian and colleagues describe the results of a clinical trial investigating the complementary capabilities of 18F-FDG and 18F-FLT in PET/CT imaging of pulmonary nodules.
Page 186

Optimal imaging strategies in multiple myeloma: Fonti and colleagues compare the contributions of 18F-FDG PET/CT, 99mTc-sestamibi scintigraphy, and MRI in whole-body and regional evaluation of patients with newly diagnosed multiple myeloma.
Page 195

PET and tumor hypoxia: Dehdashti and colleagues report on the use of pretreatment 60Cu-ATSM PET in assessing tumor oxygenation as a predictor of outcomes in patients with cervical cancer.
Page 201

Prostate acetate kinetics: Schiepers and colleagues describe models of acetate kinetics in prostate cancer and discuss the potential benefits of 1-11C-labeled acetate PET in staging and monitoring of the disease.
Page 206

Automated assessment of renal obstruction: Taylor and colleagues compare diuresis renography interpretations generated by a renal expert system with those of 3 experienced readers and outline the utility of this tool for education and clinical decision support.
Page 216

Candidates for ICD: Nagahara and colleagues assess altered autonomic function, as measured by cardiac MIBG activity, as a partial predictor of fatal cardiac events and as a method for identifying patients who would benefit most from implantable cardioverter defibrillators.
Page 225

Sympathetic mismatch in ischemic CHF: Caldwell and colleagues describe research with PET imaging to determine whether a specific presynaptic-to-postsynaptic mismatch characterizes cardiac sympathetic function in ischemic congestive heart failure.
Page 234

Abbreviating misery perfusion scans: Kobayashi and colleagues report on the development of a count-based method for shorter continuous inhalation in 15O-gas PET assessment of hemodynamic status in patients with ischemic cerebrovascular disease.
Page 242
Evaluation of 123I-ADAM imaging: Frokjaer and colleagues explore several kinetic and semiquantitative methods for assessing serotonin transporter binding using 123I- ADAM SPECT in humans.
Page 247

18F-galacto-RGD PET in breast cancer: Beer and colleagues elucidate the uptake patterns of this αvβ3-selective PET tracer in patients with invasive ductal breast cancer and describe its potential utility in assessment of angiogenesis and in treatment planning.
Page 255
GRP-receptor imaging in breast carcinoma: Van de Wiele and colleagues report on scintigraphic studies of 99mTc-RP527 uptake in human breast cancer as related to gastrin-releasing peptide receptor expression.
Page 260

Uncommon causes of thyrotoxicosis: Mittra and colleagues offer an educational overview of the less common causes of elevated free thyroid hormones and provide illustrative patient cases as well as best-practice recommendations.
Page 265
Marrow radionuclide dosimetry: Meredith and colleagues describe a novel method to correct for background radioactivity contributed from blood in large vessels that overlap the spine in image-based dosimetry of lumbar vertebrae.
Page 279
In vivo microRNA imaging: Lee and colleagues detail the development of a dual-luciferase reporter system for monitoring in vivo transcription of microRNA activity.
Page 285
Pulsed HIFU and tumor mAb uptake: Khaibullina and colleagues explore the ability of pulsed high-intensity focused ultrasound to enhance uptake of a radiolabeled monoclonal antibody to human epidermoid tumor in a mouse model.
Page 295

PET/CT and chemosensitivity: Song and colleagues investigate whether 18F-FDG PET/CT can be used for in vivo chemosensitivity testing and identify optimal time points for such imaging in cisplatin administration in rabbits with implanted squamous cell tumors.
Page 303

99mTc-His-folate SPECT/CT: Müller and colleagues report on SPECT/CT imaging of folate receptor–positive malignant and normal tissues and organs, including the salivary glands and choroid plexus, using an improved organometallic 99mTc-radiofolate.
Page 310

Bombesin analogs in tumor targeting: Cescato and colleagues describe 2 bombesin analogs, a gastrin-releasing peptide receptor agonist and an antagonist, and assess their 99mTc-labeled ligands for in vitro and in vivo tumor-targeting properties.
Page 318

1-11C-acetate and FAS expression: Vāvere and colleagues evaluate the potential value of this tracer as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer.
Page 327

ON THE COVER
The integrin αvβ3, an interesting target for specific therapies in oncology, is highly expressed on activated endothelial cells during angiogenesis and plays an important role in the regulation of tumor growth, local invasiveness, and metastatic potential. As confirmed by the immunohistochemistry images, these 18F-galacto-RGD PET images of invasive ductal breast cancer show αvβ3 expression predominantly on the neovasculature.

See page 258.