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Research ArticleCLINICAL INVESTIGATIONS

18F-FDG PET/CT, 99mTc-MIBI, and MRI in Evaluation of Patients with Multiple Myeloma

Rosa Fonti, Barbara Salvatore, Mario Quarantelli, Cesare Sirignano, Sabrina Segreto, Fara Petruzziello, Lucio Catalano, Raffaele Liuzzi, Bruno Rotoli, Silvana Del Vecchio, Leonardo Pace and Marco Salvatore
Journal of Nuclear Medicine February 2008, 49 (2) 195-200; DOI: https://doi.org/10.2967/jnumed.107.045641
Rosa Fonti
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Barbara Salvatore
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Mario Quarantelli
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Cesare Sirignano
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Sabrina Segreto
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Fara Petruzziello
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Lucio Catalano
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Raffaele Liuzzi
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Bruno Rotoli
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Silvana Del Vecchio
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Leonardo Pace
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Marco Salvatore
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    FIGURE 1. 

    Coronal, sagittal, and transaxial CT, PET, and fused images of whole-body 18F-FDG PET/CT (A), anterior and posterior whole-body 99mTc-MIBI (B), and sagittal T1- and T1-weighted fat-saturated with gadolinium MR images of spine (C). All 3 imaging modalities, performed on the same MM patient, showed a focal + diffuse pattern of distribution. In particular, focal lesions were shown in skull, humeri, pelvis, left femur, and right fibula by whole-body 18F-FDG PET/CT; in skull, right humerus, pelvis, left femur, and right fibula by whole-body 99mTc-MIBI; and in coccygeal bone by MRI of spine and pelvis.

Tables

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    TABLE 1

    Whole-Body 18F-FDG PET/CT, Whole-Body 99mTc-MIBI, and MRI of Spine and Pelvis Performed on 33 MM Patients at Diagnosis: Comparison According to Presence of Normal, Diffuse, or Focal and Focal + Diffuse Pattern of Bone Marrow Involvement

    Imaging modalityNDF-FD
    Whole-body 18F-FDG PET/CT1 (3)3 (9)29 (88)
    Whole-body 99mTc-MIBI3 (9)11 (33)19 (57)
    MRI of spine and pelvis6 (18)13 (39)14 (42)
    • N = normal; D = diffuse; F-FD = focal and focal + diffuse.

    • Values in parentheses are percentages (2-sided Fisher exact test; P < 0.005).

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    TABLE 2

    Comparison of Number of Focal Lesions per Patient Detected by Whole-Body 18F-FDG PET/CT, Whole-Body 99mTc-MIBI, and MRI of Spine and Pelvis

    Focal lesions per patient (n)
    Whole-body 18F-FDG PET/CTWhole-body 99mTc-MIBIMRI spine and pelvisKendall's W test
    5.94 ± 9.29*†1.91 ± 4.451.54 ± 2.45P < 0.001
    • ↵* P < 0.001, 18F-FDG PET/CT vs. 99mTc-MIBI.

    • ↵† P < 0.005, 18F-FDG PET/CT vs. MRI.

    • View popup
    TABLE 3

    18F-FDG PET/CT, 99mTc-MIBI, and MRI of Spinal and Pelvic District Performed on 33 MM Patients at Diagnosis: Comparison According to Presence of Normal, Diffuse, or Focal and Focal + Diffuse Pattern of Bone Marrow Involvement

    Imaging modalityNDF-FD
    Whole-body 18F-FDG PET/CT of spine and pelvis12 (36)6 (18)15 (45)
    Whole-body 99mTc-MIBI of spine and pelvis8 (24)18 (54)7 (21)
    MRI of spine and pelvis6 (18)13 (39)14 (42)
    • N = normal; D = diffuse; F-FD = focal and focal + diffuse.

    • Values in parentheses are percentages (2-sided Fisher exact test; P < 0.005).

    • View popup
    TABLE 4

    Comparison of Number of Focal Lesions per Patient Detected by 18F-FDG PET/CT, 99mTc-MIBI, and MRI of Spinal and Pelvic District

    Focal lesions per patient (n)
    18F-FDG PET/CT spine and pelvis99mTc-MIBI spine and pelvisMRI spine and pelvisKendall's W test
    2.27 ± 4.64*0.30 ± 0.681.54 ± 2.45†P < 0.005
    • ↵* P < 0.001, 18F-FDG PET/CT vs. 99mTc-MIBI.

    • ↵† P < 0.01, MRI vs. 99mTc-MIBI.

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Journal of Nuclear Medicine: 49 (2)
Journal of Nuclear Medicine
Vol. 49, Issue 2
February 2008
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18F-FDG PET/CT, 99mTc-MIBI, and MRI in Evaluation of Patients with Multiple Myeloma
Rosa Fonti, Barbara Salvatore, Mario Quarantelli, Cesare Sirignano, Sabrina Segreto, Fara Petruzziello, Lucio Catalano, Raffaele Liuzzi, Bruno Rotoli, Silvana Del Vecchio, Leonardo Pace, Marco Salvatore
Journal of Nuclear Medicine Feb 2008, 49 (2) 195-200; DOI: 10.2967/jnumed.107.045641

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18F-FDG PET/CT, 99mTc-MIBI, and MRI in Evaluation of Patients with Multiple Myeloma
Rosa Fonti, Barbara Salvatore, Mario Quarantelli, Cesare Sirignano, Sabrina Segreto, Fara Petruzziello, Lucio Catalano, Raffaele Liuzzi, Bruno Rotoli, Silvana Del Vecchio, Leonardo Pace, Marco Salvatore
Journal of Nuclear Medicine Feb 2008, 49 (2) 195-200; DOI: 10.2967/jnumed.107.045641
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