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Research ArticleCLINICAL INVESTIGATIONS

Prosthetic Vascular Graft Infection: The Role of 18F-FDG PET/CT

Zohar Keidar, Ahuva Engel, Aaron Hoffman, Ora Israel and Samy Nitecki
Journal of Nuclear Medicine August 2007, 48 (8) 1230-1236; DOI: https://doi.org/10.2967/jnumed.107.040253
Zohar Keidar
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Ahuva Engel
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Aaron Hoffman
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Ora Israel
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Samy Nitecki
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  • FIGURE 1. 
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    FIGURE 1. 

    A 54-y-old man who had received right femoropopliteal bypass graft 3 mo previously. Infection was clinically suspected because of fever and local pain in right groin. 18F-FDG PET (center) demonstrates focus of increased tracer uptake in right groin (arrow), localized by PET/CT (right) to right femoropopliteal vascular graft as seen on CT (left, arrow). Graft was considered to be involved by infectious process. Diagnosis was confirmed at surgery, and infected graft was removed.

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    FIGURE 2. 

    A 68-y-old man who had received left femoropopliteal bypass graft 18 mo previously. Infection was clinically suspected because of fever and infected surgical wound in medial aspect of left distal thigh. Coronal (top left) and transaxial (top right) 18F-FDG PET images show area of increased uptake in medial aspect of left thigh (arrows), localized by PET/CT image (bottom right) to soft-tissue swelling (arrow) adjacent to left femoropopliteal graft as seen on CT (bottom left). Patient responded rapidly to antibiotic therapy, and no vascular graft infection was evident on long-term follow-up of 14 mo.

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    TABLE 1

    Clinical Characteristics of 39 Patients with Suspected Vascular Graft Infection

    Patient no.Age (y)SexReason for referralHistory of diabetesBlood glucose (mmol/L) at time of injectionWBC count (×1,000/mm3)Suspected infected graftGraft typeGraft age (mo)PET/CT findingsFinal diagnosis
    180MFever, chillsN6013,340AortobifemoralDacron6Focal graft uptakeInfected graft
    279MFeverN16725,400AortobifemoralDacron4Focal graft uptakeInfected graft
    372MFever, pus-secreting woundN9312,800Femoroposterior tibialGore-Tex6Focal graft uptakeInfected graft
    464MLocal pain, swellingN8211,000FemorofemoralGore-Tex18Focal graft uptakeInfected graft
    562MFever, local painN789,350FemorofemoralGore-Tex2Focal graft uptakeInfected graft
    663MFever, pain, secreting fistulaN898,790FemorofemoralGore-Tex13Focal graft uptakeInfected graft
    754MGroin abscess, bacteremiaN8115,500FemoropoplitealGore-Tex11Focal graft uptakeInfected graft
    870MFever, pus-secreting surgical woundN12621,800FemoropoplitealGore-Tex1Focal graft uptakeInfected graft
    971MFever, pus-secreting surgical woundN11021,800FemoropoplitealGore-Tex6Focal graft uptakeInfected graft
    1087MFever, pus-secreting woundN10215,400FemoropoplitealGore-Tex1Focal graft uptakeInfected graft
    1154MFever, local painN8110,500FemoropoplitealGore-Tex3Focal graft uptakeInfected graft
    1271MLocal abscessN1108,700FemoropoplitealGore-Tex24Focal graft uptakeInfected graft
    1372MFever, bacteremiaN9513,500FemoropoplitealGore-Tex36Focal graft uptakeInfected graft
    1467MFever, pus-secreting woundY13013,400Iliopopliteal (extraanatomic)Gore-Tex1Focal soft-tissue uptakeInfected graft
    1569MFever, pus-secreting woundN1037,200Femoropopliteal (old)Gore-Tex60None
    Femoropopliteal (new)Gore-Tex1Focal (new) graft uptakeInfected new graft
    1650MSwelling, local painN8911,500FemoropoplitealGore-Tex1Focal graft uptakeInfected hematoma, no graft infection
    1772MFever, local painN9014,390AxillofemoralGore-Tex1Focal graft uptakeInfected hematoma, no graft infection
    1872MFever, pus-secreting woundN10212,610AortobifemoralDacron1Focal soft-tissue uptakeSoft-tissue infection, no graft involvement
    1982MFever, swellingN935,340AxillofemoralGore-Tex18Focal soft-tissue uptakeSoft-tissue infection, no graft involvement
    2080FFever, cellulitesN8510,400FemorotibialGore-Tex6Focal soft-tissue uptakeSoft-tissue infection, no graft involvement
    2159MFever, bacteremiaY10912,900FemoropoplitealGore-Tex1Focal soft-tissue uptakeSoft-tissue infection, no graft involvement
    2271FSwelling, painY1896,980FemoropoplitealGore-Tex2Focal soft-tissue uptakeSoft-tissue infection, no graft involvement
    2368MFever, infected woundN868,000FemoropoplitealGore-Tex18Focal soft-tissue uptakeSoft-tissue infection, no graft involvement
    2463MBacteremia, infected stumpN9811,150Femoropopliteal (extraanatomic)Vein120Focal soft-tissue uptakeSoft-tissue infection, no graft involvement
    2576MFever, surgical wound infectionN9212,700FemoropoplitealGore-Tex1Focal soft-tissue uptakeSoft-tissue infection, no graft involvement
    2667MFever, cellulitesY33010,700Femoropopliteal (extraanatomic)Gore-Tex60Focal soft-tissue and calcaneal uptakeSoft-tissue infection and osteomyelitis
    2744MPus-secreting wound in stump areaN1029,500IliofemoralGore-Tex7Focal soft-tissue and bone uptakeSoft tissue infection and stump osteomyelitis
    2852MFever, pus-secreting woundN986,800AortobifemoralDacron2Mild linear graft uptakeNo infection
    2954MFever, local swellingY9511,920AortobifemoralDacron24Mild linear graft uptakeNo infection
    3047MFever, lymphorrheaN9010,800AortobifemoralDacron36No uptakeNo infection
    3166MFever, local painN7226,470AortobifemoralDacron84No uptakeNo infection
    3278MPain, local swellingN1018,600AxillofemoralGore-Tex2Mild linear graft uptakeNo infection
    3379FLocal swellingN1428,630AxillofemoralGore-Tex2No uptakeNo infection
    3455MFever, wound infectionN1058,900FemoropoplitealGore-Tex1Mild linear graft uptakeNo infection
    3582FPain, swelling, lymphorrheaN979,200FemoropoplitealGore-Tex2Mild linear graft uptakeNo infection
    3672MFever, local rednessY1866,200FemoropoplitealGore-Tex1Mild linear graft uptakeNo infection
    3768MFever, local swellingY9112,400FemoropoplitealGore-Tex8Mild linear graft uptakeNo infection
    3854MBacteremia, local swellingN978,920IleopoplitealGore-Tex14Mild linear graft uptakeNo infection
    3968MExpanding hematomaY2659,300Iliopopliteal (extraanatomic)Gore-Tex4No uptakeNo infection
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Journal of Nuclear Medicine: 48 (8)
Journal of Nuclear Medicine
Vol. 48, Issue 8
August 2007
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Prosthetic Vascular Graft Infection: The Role of 18F-FDG PET/CT
Zohar Keidar, Ahuva Engel, Aaron Hoffman, Ora Israel, Samy Nitecki
Journal of Nuclear Medicine Aug 2007, 48 (8) 1230-1236; DOI: 10.2967/jnumed.107.040253

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Prosthetic Vascular Graft Infection: The Role of 18F-FDG PET/CT
Zohar Keidar, Ahuva Engel, Aaron Hoffman, Ora Israel, Samy Nitecki
Journal of Nuclear Medicine Aug 2007, 48 (8) 1230-1236; DOI: 10.2967/jnumed.107.040253
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