OtherBASIC SCIENCE INVESTIGATIONS

18F-Fluoroacetate: A Potential Acetate Analog for Prostate Tumor Imaging—In Vivo Evaluation of 18F-Fluoroacetate Versus 11C-Acetate

Datta E. Ponde, Carmen S. Dence, Nobuyuki Oyama, Joonyoung Kim, Yuan-Chuan Tai, Richard Laforest, Barry A. Siegel and Michael J. Welch
Journal of Nuclear Medicine March 2007, 48 (3) 420-428;

Article Figures & Data

Figures

  • FIGURE 1. 
    FIGURE 1. 

    Rodent biodistribution study. (A) Biodistribution of 11C-ACE in Sprague–Dawley rats (n = 5 per group) at 20 min and 1 h after injection. (B) Biodistribution of 18F-FAC in Sprague–Dawley rats (n = 5 per group) at 20 min and 1, 2, and 4 h after injection. (C) Comparison of biodistribution of 11C-ACE vs. 18F-FAC in CWR22 tumor-bearing male nu/nu mice (n = 4 per group) at 30 min after injection. Changes in biodistribution for 18F-FAC from 30 min to 2 h after injection are also shown.

  • FIGURE 2. 
    FIGURE 2. 

    Small-animal PET images of mouse show 18F-FAC uptake in CWR22 tumors implanted in left flank: 18F-FAC uptake in mouse at 30 min and 1 h and 2 h after injection of about 10.7 MBq (290 μCi). Transverse, coronal, and sagittal images are shown. Images were reconstructed by the MAP method (β = 0.1). Arrows indicate localization of tumors.

  • FIGURE 3. 
    FIGURE 3. 

    (A) PET of baboon (coronal, right; transaxial, left) taken at 1 h after administration of 370 MBq (10 mCi) of 18F-FAC. PET was performed with ECAT EXACT HR+ tomograph (Siemens CTI Corp.). (B) ROIs were placed on iliac bone and femur and SUVs were calculated. Biodistribution data of rodents showed that 18F-FAC uptake into bone increased over time (Fig. 2), whereas in baboon 18F-FAC uptake in bone was low.

Tables

  • TABLE 1

    Comparison of 11C-ACE and 18F-FAC Tumor-To-Organ Ratios After Biodistribution Study in CWR22 Tumor-Bearing Male nu/nu Mice

    Tumor-to-organ ratio11C-ACE, 30 min18F-FAC, 30 min18F-FAC, 2 h
    Blood1.60 ± 0.270.93 ± 0.171.11 ± 0.18
    Lung0.66 ± 0.091.15 ± 0.231.47 ± 0.27
    Liver0.40 ± 0.091.36 ± 0.131.65 ± 0.37
    Spleen0.22 ± 0.021.45 ± 0.171.82 ± 0.44
    Kidney0.54 ± 0.111.45 ± 0.221.70 ± 0.34
    Muscle2.32 ± 0.321.43 ± 0.141.80 ± 0.46
    Fat5.45 ± 2.683.45 ± 1.042.67 ± 1.00
    Heart1.10 ± 0.241.18 ± 0.161.33 ± 0.36
    Brain0.95 ± 0.211.49 ± 0.151.69 ± 0.32
    Bone0.72 ± 0.171.57 ± 0.240.69 ± 0.23
    Prostate1.37 ± 0.441.58 ± 0.301.55 ± 0.44

    • Animals were injected with 925 kBq (25 μCi) of 11C-ACE (n = 4) and 444 kBq (12 μCi) of 18F-FAC (n = 4).

  • TABLE 2

    Organ-to-Muscle Ratios (with Background Correction) After Injection of 18F-FAC to Male nu/nu Mice (n = 2) Implanted with CWR22 Minced Tumor Tissue in Left Flank

    Organ-to-muscle ratioMouse 1Mouse 2
    30 min1 h2 h30 min1 h2 h
    Heart1.531.461.571.631.351.48
    Vertebrae1.211.271.671.421.221.68
    Tumor1.391.191.441.561.281.40

    • About 10 MBq (270 μCi) of 18F-FAC in saline were injected.

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