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OtherBASIC SCIENCE INVESTIGATIONS

Nuclear Localizing Sequences Promote Nuclear Translocation and Enhance the Radiotoxicity of the Anti-CD33 Monoclonal Antibody HuM195 Labeled with 111In in Human Myeloid Leukemia Cells

Paul Chen, Judy Wang, Kristin Hope, Liqing Jin, John Dick, Ross Cameron, Joseph Brandwein, Mark Minden and Raymond M. Reilly
Journal of Nuclear Medicine May 2006, 47 (5) 827-836;
Paul Chen
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Judy Wang
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Kristin Hope
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Liqing Jin
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John Dick
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Ross Cameron
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Joseph Brandwein
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Mark Minden
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Raymond M. Reilly
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Article Information

vol. 47 no. 5 827-836
PubMed 
16644753

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication August 8, 2005
  • Accepted for publication September 27, 2005
  • Published online April 26, 2006.

Copyright & Usage 
© 2006 by Society of Nuclear Medicine

Author Information

  1. Paul Chen 1 ,
  2. Judy Wang 1 ,
  3. Kristin Hope 2 , 3 ,
  4. Liqing Jin 2 , 3 ,
  5. John Dick 2–5 ,
  6. Ross Cameron 6 ,
  7. Joseph Brandwein 2 ,
  8. Mark Minden 2 , 5 and
  9. Raymond M. Reilly 1 , 7 , 8
  1. 1Division of Nuclear Medicine, University Health Network, Toronto, Ontario, Canada; 2Department of Hematology/Oncology, University Health Network, Toronto, Ontario, Canada; 3Department of Cell and Molecular Biology and Department of Medical Oncology, University Health Network, Toronto, Ontario, Canada; 4Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada; 5Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; 6Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; 7Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada; and 8Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
  1. For correspondence or reprints contact: Raymond M. Reilly, PhD, Leslie Dan Faculty of Pharmacy, University of Toronto, 19 Russell St., Toronto, Ontario, M5S 2S2, Canada. E-mail: raymond.reilly{at}utoronto.ca
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Journal of Nuclear Medicine: 47 (5)
Journal of Nuclear Medicine
Vol. 47, Issue 5
May 2006
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Nuclear Localizing Sequences Promote Nuclear Translocation and Enhance the Radiotoxicity of the Anti-CD33 Monoclonal Antibody HuM195 Labeled with 111In in Human Myeloid Leukemia Cells
Paul Chen, Judy Wang, Kristin Hope, Liqing Jin, John Dick, Ross Cameron, Joseph Brandwein, Mark Minden, Raymond M. Reilly
Journal of Nuclear Medicine May 2006, 47 (5) 827-836;

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Nuclear Localizing Sequences Promote Nuclear Translocation and Enhance the Radiotoxicity of the Anti-CD33 Monoclonal Antibody HuM195 Labeled with 111In in Human Myeloid Leukemia Cells
Paul Chen, Judy Wang, Kristin Hope, Liqing Jin, John Dick, Ross Cameron, Joseph Brandwein, Mark Minden, Raymond M. Reilly
Journal of Nuclear Medicine May 2006, 47 (5) 827-836;
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