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Research ArticleCLINICAL INVESTIGATIONS

18F-FDG PET/CT for Detecting Nodal Metastases in Patients with Oral Cancer Staged N0 by Clinical Examination and CT/MRI

Heiko Schöder, Diane L. Carlson, Dennis H. Kraus, Hilda E. Stambuk, Mithat Gönen, Yusuf E. Erdi, Henry W.D. Yeung, Andrew G. Huvos, Jatin P. Shah, Steven M. Larson and Richard J. Wong
Journal of Nuclear Medicine May 2006, 47 (5) 755-762;
Heiko Schöder
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Diane L. Carlson
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Dennis H. Kraus
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Hilda E. Stambuk
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Mithat Gönen
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Yusuf E. Erdi
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Henry W.D. Yeung
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Andrew G. Huvos
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Jatin P. Shah
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Steven M. Larson
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Richard J. Wong
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Article Figures & Data

Figures

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  • FIGURE 1. 
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    FIGURE 1. 

    Schema of neck lymph node levels used for surgical and radiologic assessment.

  • FIGURE 2. 
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    FIGURE 2. 

    Flow chart shows distribution of findings.

  • FIGURE 3. 
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    FIGURE 3. 

    TP PET/CT in 53-y-old man with cancer of left oral tongue. Primary tumor is not well seen on noncontrast CT (A) but is clearly delineated on PET (B) and PET/CT fusion (C) images. (D) CT shows borderline lymph node in right level II neck but no abnormality in left neck. However, PET shows moderate 18F-FDG uptake (SUV, 4.4) in left neck (E), which on fusion images clearly localizes to a small left level II node (F).

  • FIGURE 4. 
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    FIGURE 4. 

    FP PET/CT in 50-y-old man with cancer of right oral tongue. Primary tumor is not well seen on noncontrast CT (A) but is clearly delineated on PET (B) and PET/CT fusion (C) images. (D) CT shows small lymph node in right neck level III, which shows moderate 18F-FDG uptake (SUV, 4.6) on PET image (E). Fusion image shows 18F-FDG uptake clearly within this node (F). Histopathology revealed abundant lymphocytes but no metastatic deposit.

Tables

  • Figures
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    TABLE 1

    Patient Characteristics

    CharacteristicValue
    Sex
     Male21
     Female10
    Age (y)
     Mean60 ± 12
     Range37–84
    No. of primary tumor sites
     Oral tongue24
     Gum2
     Floor of mouth4
     Base of tongue1
    No. of primary tumors
     T113
     T214
     T33
     T41
    No. of neck dissections
     Unilateral26
     Bilateral5
    Type of neck dissection
     SOHND (levels I–III)11
     Extended SOHND (levels I–IV)14
     MRND, type III (levels I–V)10
     LND (levels II–IV)1
    • SOHND = supraomohyoid neck dissection, levels I–III; extended SOHND = SOHND, levels I–IV; MRND = modified radical neck dissection, type III, levels I–V with preservation of sternocleidomastoid muscle, internal jugular vein, and spinal accessory nerve; LND = lateral neck dissection, levels II–IV.

    • View popup
    TABLE 2

    Comparison of PET/CT Findings and Histopathology

    NeckTPFPTNFNTotal
    Levels661273142
    Sides6423336
    Sensitivity (%)Specificity (%)PPV (%)NPV (%)Accuracy (%)
    Levels6795509894
    Sides6785608880
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    TABLE 3

    Analysis by Number of Neck Levels Dissected

    Levels
    LevelWith metastatic nodes (n)Dissected (n)PET TP (n)PET TN (n)PET FP (n)PET FN (n)
    I35213301
    II36422752
    III36333210
    IV25002500
    V10001000
    Total1429612763
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    TABLE 4

    TP and FP PET Findings by Lymph Node (LN) Level

    Patient no.Nodal levelCT short-axis diameter (mm)Histologic largest diameter of metastasis (mm)ECS (yes/no)PET visual gradeSUV
    TP findings
    20IIILN 1: 11 × 815−5 +6.2
    LN 2: 8 × 67−3 +2.8
    11II8 × 533 +3.0
    30III14 × 1016+5 +4.4*
    8 × 411−−−
    31I (L)7 × 68+3 +4.5
    II (R)14 × 1110−4 +4.9
    26III11 × 50.3−5 +5.6
    FP findings
    5II12 × 115 +5.7
    19II10 × 84 +3.9
    24II10 × 83 +2.7
    27II11 × 75 +4.6
    III9 × 85 +4.6
    26†II6 × 54 +3.5
    • ↵* Only 1 PET-positive LN, but both metastatic nodes in the same level.

    • ↵† Patient also had a TP node in level III.

    • ECS = extracapsular spread of metastatic disease from LN (+ = yes; − = no); L = left; R = right.

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Journal of Nuclear Medicine: 47 (5)
Journal of Nuclear Medicine
Vol. 47, Issue 5
May 2006
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18F-FDG PET/CT for Detecting Nodal Metastases in Patients with Oral Cancer Staged N0 by Clinical Examination and CT/MRI
Heiko Schöder, Diane L. Carlson, Dennis H. Kraus, Hilda E. Stambuk, Mithat Gönen, Yusuf E. Erdi, Henry W.D. Yeung, Andrew G. Huvos, Jatin P. Shah, Steven M. Larson, Richard J. Wong
Journal of Nuclear Medicine May 2006, 47 (5) 755-762;

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18F-FDG PET/CT for Detecting Nodal Metastases in Patients with Oral Cancer Staged N0 by Clinical Examination and CT/MRI
Heiko Schöder, Diane L. Carlson, Dennis H. Kraus, Hilda E. Stambuk, Mithat Gönen, Yusuf E. Erdi, Henry W.D. Yeung, Andrew G. Huvos, Jatin P. Shah, Steven M. Larson, Richard J. Wong
Journal of Nuclear Medicine May 2006, 47 (5) 755-762;
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