OtherBasic Science Investigations

Time Course of Discordant BMIPP and Thallium Uptake After Ischemia and Reperfusion in a Rat Model

Takahiro Higuchi, Junichi Taki, Kenichi Nakajima, Seigo Kinuya, Masanobu Namura and Norihisa Tonami
Journal of Nuclear Medicine January 2005, 46 (1) 172-175;

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    Schematic diagram illustrating protocol of ischemia and reperfusion in rat experimental model. After reperfusion, groups of animals were allowed to recover for various intervals ranging from 20 min to 30 d before tracer injection. MIBI = sestamibi.

  • FIGURE 2.
    FIGURE 2.

    201Tl and BMIPP uptake ratios calculated by stimulated luminescence in area at risk divided by that in normally perfused areas. 201Tl uptake ratios did not change significantly after reperfusion. However, BMIPP uptake ratios were affected markedly in a time-dependent fashion. When these 2 tracers were compared at the same time point, BMIPP uptake ratios were higher than 201Tl uptake ratios at 20 min and 1 d and lower at 7 d after ischemia and reperfusion. *P < 0.05. †P < 0.001.

  • FIGURE 3.
    FIGURE 3.

    Autoradiograms of hearts of rats. BMIPP was injected at 20 min and at 1, 3, 7, and 30 d after the 20-min occlusion and reperfusion of left coronary artery. Midventricular slices serve as representatives for each group. 99mTc-Sestamibi defects demonstrate area at risk (indicated by arrows in the left column). 201Tl uptake (middle column) in area at risk is relatively unchanged in comparison with that in unaffected area. In contrast, BMIPP uptake increases at 20 min and at 1 d (arrows), decreases at 7 d (arrows), and subsequently recovers at 30 d (right column). MIBI = sestamibi.

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