Article Figures & Data
Figures
- FIGURE 1.
Preoperative HBS in patient 13, with a proximal cholangiocarcinoma. (A) Reframed images of the dynamic acquisition. Homogeneous liver uptake with moderate cholestasis is seen in the left side, without functional repercussion. (B) A summed image from 150 to 350 s after intravenous injection of 80 MBq of 99mTc-mebrofenin, with an ROI drawn semiautomatically (threshold, 20%) around the entire liver and a second ROI drawn in the mediastinum (blood pool). (C) A blood-pool–corrected liver-uptake time–activity curve. Liver uptake (d) is calculated as the increase in specific (corrected for blood pool) 99mTc-mebrofenin uptake (y-axis) per minute over a period of 200 s (x-axis).
- FIGURE 2.
Scatter plots with linear regression line of HBS liver function calculation reproducibility (A), HBS and ICG clearance LFR assessment (B), HBS preoperative and postoperative (postop.) RLF measurement (C), and liver volume and function recovery (D).
- FIGURE 3.
Bland–Altman plots of hepatic 99mTc-mebrofenin uptake, expressed as percentage uptake per minute. (A) A plot of the mean of the repeated liver uptake function calculation on HBS in 45 studies (horizontal axis) vs. the differences in the repeated calculations (vertical axis). (B) A plot of the mean of FLR determination on HBS before and after surgery in 15 studies (horizontal axis) vs. the differences in the repeated measurements (vertical axis). The horizontal solid lines indicate the mean difference between the 2 calculations. The horizontal dashed lines indicate the 95% limits of agreement (mean ± 1.96 SD).
- FIGURE 4.
Summed images of patient 3 from 150 to 350 s after intravenous injection of 80 MBq of 99mTc-mebrofenin preoperatively (A), 1 d postoperatively after right-sided hemihepatectomy (B), and 3 mo postoperatively (C). Images are normalized to the preoperative HBS. In A, an ROI is drawn over the entire liver (black), the future remnant liver (white), and the mediastinal blood pool (bl). The ROIs were copied on the HBS performed 1 d and 3 mo postoperatively. The total liver function was 16.05%/min, and the RLF was estimated at 5.88%/min on preoperative HBS. The measured RLF 1 d postoperatively was 5.15%/min. After 3 mo, liver function recovered to 12.80%/min, with hypertrophy visible on HBS.
- FIGURE 5.
Summed images of patient 15 from 150 to 350 s after intravenous injection of 80 MBq of 99mTc-mebrofenin preoperatively (A), 1 d postoperatively after left-sided hemihepatectomy (B), and 3 mo postoperatively (C). Images are normalized to the preoperative HBS. In A, an ROI is drawn over the entire liver (black), the future remnant liver (white), and the mediastinal blood pool (bl). The ROIs were copied on the HBS performed 1 d and 3 mo postoperatively. The total liver function was 10.30%/min, and the RLF was estimated at 8.99%/min on preoperative HBS. The measured RLF 1 d postoperatively was 9.30%/min. After 3 mo, liver function recovered to 11.79%/min, with hypertrophy visible on HBS.
Tables
Patient no. Preoperative Perioperative Postoperative ICG (%) CT (mL) HBS (%/min) RLFHBS (%/min) VolRes (mL) VolRem (mL) HBS (%/min) 1 95.80 1,318 14.55 6.41 800 518 5.64 2 91.63 1,739 11.70 4.89 1,000 739 4.61 3 98.57 1,285 16.05 5.88 800 485 5.15 4 96.31 2,346 18.45 8.10 950 1,396 8.43 5 90.81 1,518 11.51 7.37 900 618 8.67 6 94.54 1,353 15.55 12.23 500 853 11.7 7 89.69 1,887 14.71 12.14 700 1,187 13.97 8 87.20 1,616 10.18 8.35 200 1,416 8.82 9 96.37 1,759 16.72 7.97 800 959 7.25 10 90.61 2,825 13.62 4.19 1,300 1,525 3.06 11 94.26 3,312 13.85 9.10 1,100 2,212 9.38 12 93.23 1,668 14.96 5.27 700 966 4.08 13 89.24 1,942 12.39 5.81 1,200 742 4.65 14 87.23 1,282 10.77 4.96 400 882 4.79 15 86.44 982 10.30 8.89 400 582 9.30 RLFHBS = RLF determined on preoperative HBS.
VolRes = Surgically resected volume.
VolRem = Volume of remnant liver.
Patient no. HBSPost (%/min) HBS3M (%/min) VolPost (mL) Vol3M (mL) HBSRec (%/min) VolRec (mL) 1 5.64 12.80 518 960 7.16 442 2 4.61 11.84 739 1,277 7.23 537 3 5.15 14.52 485 1,086 9.37 601 4 8.43 12.33 1,396 1,558 3.90 162 5 8.67 10.18 618 914 1.51 296 6 11.7 12.71 853 1,177 1.01 324 7 13.97 9.30 1,187 1,327 −4.67 140 8 8.82 11.14 1,416 1,381 2.32 −35 9 7.25 13.60 959 1,047 6.35 87 10 3.06 4.15 1,525 1,530 1.09 5 11 9.38 14.20 2,212 2,592 4.82 380 12 4.08 9.94 966 1,356 5.86 389 13 4.65 7.83 742 947 3.18 206 14 4.79 9.76 882 955 4.97 72 15 9.30 11.79 582 913 2.49 331 Post = Assessment 1 d after surgery.
3M = Assessment 3 mo after surgery.
HBSRec = Functional recovery determined with HBS.
VolRec = Volume recovery determined with CT.
In this issue
Jump to section
Related Articles
Cited By...
- Liver Intrinsic Function Evaluation (LIFE): Multi-parametric Liver Function Profiles of Patients Undergoing Hepatectomy
- A Pilot Study on Hepatobiliary Scintigraphy to Monitor Regional Liver Function in 90Y Radioembolization
- Evaluation of liver regeneration and post-hepatectomy liver failure after hemihepatectomy in patients with hepatocellular carcinoma
- The Role of Organic Anion Transporters in Diagnosing Liver Diseases by Magnetic Resonance Imaging
- Quantitative Assessment of Hepatic Function During Liver Regeneration in a Standardized Rat Model
- Nuclear Imaging Techniques for the Assessment of Hepatic Function in Liver Surgery and Transplantation
- Comparison Between the Values of the Hepatic Uptake Rate Obtained by 2 Methods, Using Hepatobiliary Scintigraphy in Patients with Nonalcoholic Steatohepatitis
- 99mTc-Mebrofenin Hepatobiliary Scintigraphy with SPECT for the Assessment of Hepatic Function and Liver Functional Volume Before Partial Hepatectomy
- 99mTc-GSA Scintigraphy with SPECT for Assessment of Hepatic Function and Functional Volume During Liver Regeneration in a Rat Model of Partial Hepatectomy
- Risk Assessment of Posthepatectomy Liver Failure Using Hepatobiliary Scintigraphy and CT Volumetry