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OtherBasic Science Investigations

Preclinical Evaluation of 99mTc-EC20 for Imaging Folate Receptor–Positive Tumors

Joseph A. Reddy, Le-Cun Xu, Nikki Parker, Marilynn Vetzel and Christopher P. Leamon
Journal of Nuclear Medicine May 2004, 45 (5) 857-866;
Joseph A. Reddy
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Le-Cun Xu
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Nikki Parker
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Marilynn Vetzel
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Christopher P. Leamon
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Article Information

vol. 45 no. 5 857-866
PubMed 
15136637

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Published online May 10, 2004.

Copyright & Usage 
THE JOURNAL OF NUCLEAR MEDICINE

Author Information

  1. Joseph A. Reddy, PhD,
  2. Le-Cun Xu, PhD,
  3. Nikki Parker, BS,
  4. Marilynn Vetzel, BS and
  5. Christopher P. Leamon, PhD
  1. Endocyte, Inc., West Lafayette, Indiana
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Journal of Nuclear Medicine: 45 (5)
Journal of Nuclear Medicine
Vol. 45, Issue 5
May 1, 2004
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Preclinical Evaluation of 99mTc-EC20 for Imaging Folate Receptor–Positive Tumors
Joseph A. Reddy, Le-Cun Xu, Nikki Parker, Marilynn Vetzel, Christopher P. Leamon
Journal of Nuclear Medicine May 2004, 45 (5) 857-866;

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Preclinical Evaluation of 99mTc-EC20 for Imaging Folate Receptor–Positive Tumors
Joseph A. Reddy, Le-Cun Xu, Nikki Parker, Marilynn Vetzel, Christopher P. Leamon
Journal of Nuclear Medicine May 2004, 45 (5) 857-866;
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  • A 99mTc-Labeled Ligand of Carbonic Anhydrase IX Selectively Targets Renal Cell Carcinoma In Vivo
  • Imaging the Folate Receptor on Cancer Cells with 99mTc-Etarfolatide: Properties, Clinical Use, and Future Potential of Folate Receptor Imaging
  • Exploiting Endocytosis for Nanomedicines
  • DOTA Conjugate with an Albumin-Binding Entity Enables the First Folic Acid-Targeted 177Lu-Radionuclide Tumor Therapy in Mice
  • A New 18F-Labeled Folic Acid Derivative with Improved Properties for the PET Imaging of Folate Receptor-Positive Tumors
  • In Vivo Assay of Folate Receptors in Nonfunctional Pituitary Adenomas with 99mTc-Folate SPECT/CT
  • Imaging of Atherosclerosis in Apoliprotein E Knockout Mice: Targeting of a Folate-Conjugated Radiopharmaceutical to Activated Macrophages
  • A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages
  • Impact of High and Low Folate Diets on Tissue Folate Receptor Levels and Antitumor Responses Toward Folate-Drug Conjugates
  • Folate Targeting Enables Durable and Specific Antitumor Responses from a Therapeutically Null Tubulysin B Analogue
  • Exploratory Study of 99mTc-EC20 Imaging for Identifying Patients with Folate Receptor-Positive Solid Tumors
  • Pemetrexed Improves Tumor Selectivity of 111In-DTPA-Folate in Mice with Folate Receptor-Positive Ovarian Cancer
  • SPECT Study of Folate Receptor-Positive Malignant and Normal Tissues in Mice Using a Novel 99mTc-Radiofolate
  • In vivo quantitation of rare circulating tumor cells by multiphoton intravital flow cytometry
  • Folate Receptor-Specific Antitumor Activity of EC131, a Folate-Maytansinoid Conjugate
  • Preclinical Evaluation of EC145, a Folate-Vinca Alkaloid Conjugate
  • Preclinical pharmacokinetics, tissue distribution, and antitumor activity of a folate-hapten conjugate-targeted immunotherapy in hapten-immunized mice
  • Effects of Antifolate Drugs on the Cellular Uptake of Radiofolates In Vitro and In Vivo
  • The Use of a Tropism-Modified Measles Virus in Folate Receptor-Targeted Virotherapy of Ovarian Cancer.
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