Article Figures & Data
Figures
- FIGURE 1.
(A) Transaxial sections from a SPECT RCBF scan of a patient with autopsy-proven AD. Arrows indicate the posterior cingulate/retrosplenial cortex. Additional areas of reduced flow are seen bilaterally in the posterior parietal regions. (B) Midline and near-midline sagittal sections from the RCBF SPECT study of the same patient. Arrows indicate posterior cingulate and retrosplenial areas of reduced blood flow.
- FIGURE 2.
Selected transaxial sections from the RCBF SPECT study of a 67-y-old woman referred for imaging because of a diagnosis of possible frontotemporal dementia. The posterior cingulate sign is present in the posterior midline. With continuing evaluation of the patient, her diagnosis is now probable AD.
Tables
- TABLE 1
Identification of Posterior Cingulate Flow Deficits by SPECT and Statistical Parametric Mapping
20 patients with AD 20 patients with FTD PC No PC PC No PC 16 (6) 4 (4) 1 19 (7) PC = posterior cingulate sign.
Proportion 95% Confidence interval Lower limit Upper limit Sensitivity: 16/20 = 80.00% 55.73% 93.39% Specificity: 19/20 = 95.00% 73.06% 99.74% Positive predictive value: 16/17 = 94.12% 69.24% 99.69% Negative predictive value: 19/23 = 82.61% 60.45% 94.28% % Correct: 35/40 = 87.50% 72.40% 95.31% Likelihood ratio: 16.00 12.64 20.26
