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OtherClinical Investigations

Comparison of Gated PET with MRI for Evaluation of Left Ventricular Function in Patients with Coronary Artery Disease

Riemer H.J.A. Slart, Jeroen J. Bax, Richard M. de Jong, Jaep de Boer, Hildo J. Lamb, Piet H. Mook, Antoon T.M. Willemsen, Willem Vaalburg, Dirk J. van Veldhuisen and Pieter L. Jager
Journal of Nuclear Medicine February 2004, 45 (2) 176-182;
Riemer H.J.A. Slart
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Jeroen J. Bax
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Richard M. de Jong
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Jaep de Boer
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Hildo J. Lamb
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Piet H. Mook
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Antoon T.M. Willemsen
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Willem Vaalburg
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Dirk J. van Veldhuisen
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Pieter L. Jager
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  • FIGURE 1.
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    FIGURE 1.

    Images from QGS of end-diastolic (A) and end-systolic (B) phases showing epicardial and endocardial borders of the left ventricle. SEPT = septal; LAT = lateral.

  • FIGURE 2.
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    FIGURE 2.

    Transverse 2-chamber view of end-diastolic (A) and end-systolic (B) phases of the left ventricle. Epicardial and endocardial contours are automatically drawn, but incorrect contours can be corrected manually.

  • FIGURE 3.
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    FIGURE 3.

    Relationship between summed wall motion scores (WMS) per patient on MRI and on gated 18F-FDG PET.

  • FIGURE 4.
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    FIGURE 4.

    Agreement between regional wall motion scores per segment on MRI and on gated 18F-FDG PET. Basal segments: 1 = anterior; 2 = lateral; 3 = inferior; 4 = septal. Distal segments: 5 = anterior; 6 = lateral; 7 = inferior; 8 = septal. 9 = apical segment. Mean = mean agreement for all 9 segments ± SEE.

  • FIGURE 5.
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    FIGURE 5.

    (A) Relationship between LVESV assessed by MRI and gated 18F-FDG PET. (B) Bland–Altman plot for LVESV without a systematic trend.

  • FIGURE 6.
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    FIGURE 6.

    (A) Relationship between LVEDV assessed by MRI and gated 18F-FDG PET. (B) Bland–Altman plot for LVEDV without a systematic trend.

  • FIGURE 7.
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    FIGURE 7.

    (A) Relationship between LVEF assessed by MRI and gated 18F-FDG PET. (B) Bland–Altman plot for LVEF without a systematic trend.

Tables

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    TABLE 1

    Patient Characteristics

    ParameterValue*
    Patients38
     Male28
     Female10
     Mean ± SD age (y)66 ± 9
    Medical history
     Myocardial infarction28
     Coronary angioplasty7
     Coronary artery bypass graft2
     Diabetes mellitus10
     Systemic hypertension7
    CAD
     One vessel7
     Two vessels15
     Three vessels16
     Angina pectoris†28
    • ↵* Reported as number of patients unless indicated otherwise.

    • ↵† Canadian Cardiovascular Society classes 1–4.

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    TABLE 2

    Agreement Between MRI and Gated 18F-FDG PET for Assessment of Regional Wall Motion Score (RWMS)

    RWMS on MRINo. of segments with the following RWMS on gated PET:
    012Total
    0136221159
    1101035118
    20124355
    Total14613749332
    • Agreement was excellent (85%; κ-statistic, 0.79).

    • View popup
    TABLE 3

    Measurements of LV Volumes and LVEF by MRI and Gated 18F-FDG PET

    MeasurementValue determined by:P
    MRIGated PET
    LVESV
     Mean (mL)91 ± 1285 ± 510.57
     Range (mL)31–20224–198
    LVEDV
     Mean (mL)131 ± 57117 ± 56<0.001
     Range (mL)61–26741–242
    LVEF
     Mean (%)33 ± 1230 ± 11<0.001
     Range14–5913–55
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Journal of Nuclear Medicine
Vol. 45, Issue 2
February 1, 2004
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Comparison of Gated PET with MRI for Evaluation of Left Ventricular Function in Patients with Coronary Artery Disease
Riemer H.J.A. Slart, Jeroen J. Bax, Richard M. de Jong, Jaep de Boer, Hildo J. Lamb, Piet H. Mook, Antoon T.M. Willemsen, Willem Vaalburg, Dirk J. van Veldhuisen, Pieter L. Jager
Journal of Nuclear Medicine Feb 2004, 45 (2) 176-182;

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Comparison of Gated PET with MRI for Evaluation of Left Ventricular Function in Patients with Coronary Artery Disease
Riemer H.J.A. Slart, Jeroen J. Bax, Richard M. de Jong, Jaep de Boer, Hildo J. Lamb, Piet H. Mook, Antoon T.M. Willemsen, Willem Vaalburg, Dirk J. van Veldhuisen, Pieter L. Jager
Journal of Nuclear Medicine Feb 2004, 45 (2) 176-182;
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