Abstract
The aim of this study was to compare left ventricular (LV) volumes and regional wall motion determined by PET with those determined by the reference technique, cardiovascular MRI. Methods: LV end-diastolic volume (LVEDV), LV end-systolic volume (LVESV), and LV ejection fraction (LVEF) were measured and regional wall motion was scored in 38 patients with chronic coronary artery disease by both gated 18F-FDG PET and MRI. A 9-segment model was used for PET and MRI to assess regional wall motion. Results: Good correlations were observed between MRI and gated PET for all parameters (r values ranging from 0.91 to 0.96). With PET, there was a significant but small underestimation of LVEDV and LVEF. Mean ± SD LVEDV, LVESV, and LVEF for MRI were 131 ± 57 mL, 91 ± 12 mL, and 33% ± 12%, respectively, and those for gated PET were 117 ± 56 mL, 85 ± 51 mL, and 30% ± 11%, respectively. For regional wall motion, an agreement of 85% was found, with a κ-statistic of 0.79 (95% confidence interval, 0.70–0.89; SE, 0.049). Conclusion: LV volumes, LVEF, and regional wall motion can be assessed with gated 18F-FDG PET and correlate well with these parameters assessed by MRI.
Footnotes
Received Apr. 21, 2003; revision accepted Oct. 23, 2003.
For correspondence or reprints contact: Riemer H.J.A. Slart, MD, Department of Nuclear Medicine and PET-Center, Groningen University Medical Center, Hanzeplein 1, P.O. Box 30001, 9700 RB Groningen, The Netherlands.
E-mail: r.slart{at}nucl.azg.nl
