OtherCLINICAL INVESTIGATIONS

Automatic Determination of Left Ventricular Ejection Fraction from Gated Blood-Pool Tomography

Christian Vanhove, Philippe R. Franken, Michel Defrise, Afsana Momen, Hendrik Everaert and Axel Bossuyt
Journal of Nuclear Medicine March 2001, 42 (3) 401-407;

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    Horizontal long-axis slice at end-diastole (A) and end-systole (B). Subtracting end-systolic image from end-diastolic image (C) results in positive values around ventricles (dark gray) and negative values around auricles (light gray).

  • FIGURE 2.
    FIGURE 2.

    Detecting septum is done on best septal view at end-diastole. By summing all voxels along x-axis, profile is generated. Maximum (A) is selected, and another profile along this location is created. Local minimum (B) is selected as septum, and local maximum on left side of septum (C) is selected as center of left ventricle.

  • FIGURE 3.
    FIGURE 3.

    Summary of algorithm. Initially, end-diastolic image (A) is segmented (B) and segments are identified (C) as left and right ventricle. Optimal threshold is found when corresponding ventricular wall (D) best fits first derivative of end-diastolic count distribution (E).

  • FIGURE 4.
    FIGURE 4.

    Linear regression analysis (A) and Bland-Altman plot (B) between LVEF determined by GBPT and LVEF determined by PRNA.

  • FIGURE 5.
    FIGURE 5.

    Intraobserver reproducibility. Linear regression (A) and Bland-Altman analysis (B) between original LVEFs measured (LVEF 1) and ejection fraction measured 3 mo later (LVEF 2).

  • FIGURE 6.
    FIGURE 6.

    Agreement between LVEFs measured by two independent observers.

Tables

  • TABLE 1

    Effect of Reconstruction Filter

    Cutoff frequencyCycles per centimeter
    0.250.300.350.400.45
    r0.780.880.890.880.86
    Slope1.511.301.091.101.11
    Intercept−19.58−11.21−0.72−0.67−1.26
    Systematic error (%)+6.95+4.55+3.80+4.45+4.50
    Random error (%)15.999.326.767.277.92
    P0.070.040.020.010.02
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