OtherCLINICAL INVESTIGATIONS

Quantification of Myocardial Perfusion in Human Subjects Using 82Rb and Wavelet-Based Noise Reduction

Jou-Wei Lin, Robert R. Sciacca, Ru-Ling Chou, Andrew F. Laine and Steven R. Bergmann
Journal of Nuclear Medicine February 2001, 42 (2) 201-208;

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    Imaging protocol. Each subject had a transmission scan followed by emission scans at rest with 82Rb and H215O. Dipyridamole was infused to induce hyperemia. Another set of emission images was obtained starting 3–4 min after end of dipyridamole administration.

  • FIGURE 2.
    FIGURE 2.

    Two-compartment model describes kinetic behavior of 82Rb in myocardium. Q1(t) and Q2(t) = 82Rb activity in extracellular (intravascular and interstitial) and intracellular spaces, respectively; MBF = myocardial blood flow; k1 and k2 = forward and backward rates of transport between two compartments; Vd = distribution volume of free 82Rb in myocardium; FBM = spillover fraction from myocardial blood pool to myocardial tissue; Ca(t) = radioactivity in blood pool.

  • FIGURE 3.
    FIGURE 3.

    Myocardial short-axis images obtained from last 30-s frame after administration of 82Rb before (A) and after (B) wavelet-based noise reduction. Contour of heart became clearer and homogeneity of tissue counts increased after wavelet processing.

  • FIGURE 4.
    FIGURE 4.

    Blood (dotted line) and tissue (solid line) time–activity curves of representative ROI after administration of 82Rb before (A) and after (B) wavelet-based noise reduction. Dynamic curves became smoother, yet dynamics in early frames were still preserved.

  • FIGURE 5.
    FIGURE 5.

    Correlation of global flow obtained from human subjects with H215O (x-axis) and 82Rb (y-axis) combining resting and hyperemic flows. (A) Original protocol with 82Rb before wavelet-based noise reduction. (B) After wavelet-based noise reduction. Wavelet protocol improved correlation considerably over wide range of flows. MBF = myocardial blood flow; b0 = intercept; b1 = slope of line.

  • FIGURE 6.
    FIGURE 6.

    Bland–Altman plots between global flows obtained from H215O studies and 82Rb studies before (A) and after (B) wavelet denoising. Plots show reduction in bias and limits of agreement after wavelet approach.

  • FIGURE 7.
    FIGURE 7.

    COVs, which represent regional variation of flow estimates, were reduced significantly after wavelet process at rest and after dipyridamole.

Tables

  • TABLE 1.

    Hemodynamics for Healthy Volunteers During PET Studies

    Volunteer no.RB1HO1RB2HO2
    HRSBPDBPMAPHRSBPDBPMAPHRSBPDBPMAPHRSBPDBPMAP
     163824457638658678192526583925668
     25196546851965468981085271851135574
     3591327292581167488801268095751298096
     4641065874661025671911086277811105875
     5591135373661125473991316889921286083
     6611197187651216483981257088971246887
     7731327997831326587931446088931506593
     8741186885731207087831186683821206986
     96913678976913678979813078958414083102
    10631376186551467095891446491881466491
    114198526742965065701014966571015067
    Mean ± SD62 ± 9115 ± 1863 ± 1280 ± 1363 ± 11115 ± 1963 ± 980 ± 1289 ± 10*121 ± 17*64 ± 1083 ± 1183 ± 11*†123 ± 18*64 ± 1084 ± 12

    • ↵* P < 0.05 for comparison between resting and hyperemic studies on each hemodynamic measurement.

    • ↵† P < 0.05 for comparison between H215O and 82Rb scans on each hemodynamic measurement.

    • HR = heart rate (beats/min); SBP = systolic blood pressure (mm Hg); DBP = diastolic blood pressure (mm Hg); MAP = mean arterial pressure (mm Hg).

    • RB1 and RB2 represent 82Rb studies before and after dipyridamole administration; HO1 and HO2 represent H215O studies. Administration of dipyridamole significantly increased heart rate and systolic blood pressure. Heart rate of HO2 was slightly lower than that of RB2.

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