OtherBasic Science Investigations

Tumor Response After [90Y-DOTA0,Tyr3]Octreotide Radionuclide Therapy in a Transplantable Rat Tumor Model Is Dependent on Tumor Size

Marion de Jong, Wout A.P. Breeman, Bert F. Bernard, Willem H. Bakker, Theo J. Visser, Peter P.M. Kooij, Arthur van Gameren and Eric P. Krenning
Journal of Nuclear Medicine December 2001, 42 (12) 1841-1846;

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    Structures of octreotide, [Tyr3]octreotide, and DOTA.

  • FIGURE 2.
    FIGURE 2.

    Survival curves of rats bearing small (≤1 cm2; solid line) vs. large (≥10 cm2; dashed line) CA20948 tumors after no administration (control) or 111 MBq [90Y-DOTA0,Tyr3]octreotide administration. For all groups, n = 8.

  • FIGURE 3.
    FIGURE 3.

    Tumor responses found in rats bearing small (≤1 cm2) vs. large (≥10 cm2) CA20948 tumors after no administration (control) or 111 MBq [90Y-DOTA0,Tyr3]octreotide administration. NR = no response; PR = partial response; CR = complete response. For all groups, n = 8.

  • FIGURE 4.
    FIGURE 4.

    Tumor responses found in rats bearing very small (≤0.1 cm2; n = 10), small (≤1 cm2; n = 8), medium (3–9 cm2; n = 7), or large (≥14 cm2; n = 8) CA20948 tumors after 370 MBq [90Y-DOTA0,Tyr3]octreotide administration. PR = partial response; CR = complete response.

  • FIGURE 5.
    FIGURE 5.

    Survival curves of rats bearing very small (≤0.1 cm2; n = 10), small (≤1 cm2; n = 8), medium (3–9 cm2; n = 7), or large (≥14 cm2; n = 8) CA20948 tumors after 370 MBq [90Y-DOTA0,Tyr3]octreotide administration.

  • FIGURE 6.
    FIGURE 6.

    Tumor volumes (3–9 cm2 at onset of therapy on day 24) in rats as function of time after implantation and injection of 370 MBq [90Y-DOTA0,Tyr3]octreotide at 24 d after implantation (n = 7).

Tables

  • TABLE 1

    Median Survival Time for Rats Bearing CA20948 Tumors of Different Sizes After Injection of Indicated Activities of [90Y-DOTA0,Tyr3]Octreotide

    Activity MBqMedian survival time (d)
    ≤0.1-cm2 tumors≤1-cm2 tumors3- to 9-cm2 tumors≥10 cm2 tumors
    039393638
    1 × 111ND63ND53
    1 × 370135131Undefined*66

    • ↵* Median survival time cannot be calculated when survival is >50%.

    • ND = not done.

    • For all groups, n = 8.

  • TABLE 2

    Radioactivity in CA20948 Rat Tumors

    ParameterTime (h)Tumor (g)
    Radioactivity* (%IA/g)
     0.9 ± 0.11
     0.8 ± 0.14
     0.75 ± 0.124
     0.4 ± 0.0548
     0.2 ± 0.0372
    Absorbed dose
     Per injected activity (mGy/MBq)
      1301
      16010
     After 370 MBq [90Y-DOTA0,Tyr3]octreotide (Gy)
      481
      6010

    • ↵* Percentage of injected activity per gram of tumor (mean ± SD) at various times after injection of [90Y-DOTA0,Tyr3]octreotide (3 MBq coupled to 12 μg); n ≥ 3 in each group.

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