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OtherClinical Investigations

Quantitative Analysis of Regional Motion and Thickening by Gated Myocardial Perfusion SPECT: Normal Heterogeneity and Criteria for Abnormality

Tali Sharir, Daniel S. Berman, Parker B. Waechter, Joseph Areeda, Paul B. Kavanagh, Jim Gerlach, Xingping Kang and Guido Germano
Journal of Nuclear Medicine November 2001, 42 (11) 1630-1638;
Tali Sharir
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Daniel S. Berman
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Parker B. Waechter
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Joseph Areeda
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Paul B. Kavanagh
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Jim Gerlach
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Xingping Kang
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Guido Germano
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  • FIGURE 1.
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    FIGURE 1.

    Schematic representation of 20-segment model of left ventricle.

  • FIGURE 2.
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    FIGURE 2.

    Plot of normal motion and thickening (mean ± SEM) at 4 levels from apex to base.

  • FIGURE 3.
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    FIGURE 3.

    Circumferential variations in normal segmental motion at distal, mid, and basal ventricular levels.

  • FIGURE 4.
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    FIGURE 4.

    Circumferential variations in normal segmental thickening at distal, mid, and basal ventricular levels.

  • FIGURE 5.
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    FIGURE 5.

    Thresholds (number of SDs below reference value) for defining motion (A) and thickening (B) abnormalities.

  • FIGURE 6.
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    FIGURE 6.

    Overall sensitivity (black bars) and specificity (white bars) in detecting segmental motion and thickening abnormalities by quantitative algorithm in validation group.

  • FIGURE 7.
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    FIGURE 7.

    Segment-by-segment sensitivity (black bars) and specificity (white bars) in detecting motion (A) and thickening (B) abnormalities by quantitative algorithm in validation group.

  • FIGURE 8.
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    FIGURE 8.

    Correlation between quantitative versus visual summed motion score (A) and summed thickening score (B). Solid line indicates linear fit and dashed line indicates line of identity.

Tables

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    TABLE 1

    Patient Characteristics

    ParameterLow likelihood (n = 64)Training (n = 101)Validation (n = 100)
    Age (y)56 ± 11*†65 ± 1264 ± 13
    Men33 (52%)65 (64%)63 (63%)
    History of myocardial infarction0 (0%)*†35 (34.7%)31 (31%)
    History of coronary angioplasty0 (0%)*†24 (23.8%)26 (26%)
    History of bypass surgery0 (0%)*†10 (9.9%)12 (12%)
    Diabetes mellitus1 (1.5%)*†17 (16.8%)11 (11%)
    Hypertension0 (0%)†47 (64.5%)57 (57%)
    Typical angina0 (0%)*†16 (15.8%)15 (15%)
    Shortness of breath5 (7.8%)14 (13.9%)11 (11%)
    Prescan likelihood of CAD0.02 ± 0.01*†0.63 ± 0.410.60 ± 0.40
    Summed stress score0.3 ± 1.0*†11 ± 119 ± 10
    Summed rest score0 ± 0*†5 ± 84 ± 8
    Summed difference score0.3 ± 1.0*†6 ± 85 ± 6
    Ejection fraction (%)66 ± 8*†46 ± 1743_16
    • ↵* P < 0.05 versus training group.

    • ↵† P < 0.05 versus validation group.

    • CAD = coronary artery disease.

    • View popup
    TABLE 2

    Reference Values for Segmental Motion and Thickening

    SegmentLocationMotion (mm)Thickening (%)
    1Anteroapical8.4 ± 1.868 ± 14
    2Inferoapical9.1 ± 1.869 ± 13
    3Distal anterior8.1 ± 1.559 ± 13
    4Distal anteroseptal7.2 ± 1.658 ± 13
    5Distal inferoseptal7.2 ± 1.661 ± 12
    6Distal inferior9.1 ± 1.660 ± 13
    7Distal inferolateral9.5 ± 1.760 ± 14
    8Distal anterolateral9.2 ± 1.761 ± 13
    9Mid anterior8.6 ± 1.448 ± 10
    10Mid anteroseptal6.7 ± 1.645 ± 11
    11Mid inferoseptal5.9 ± 1.643 ± 9
    12Mid inferior7.2 ± 1.345 ± 11
    13Mid inferolateral8.1 ± 1.549 ± 12
    14Mid anterolateral8.3 ± 1.548 ± 12
    15Basal anterior9.0 ± 1.623 ± 10
    16Basal anteroseptal5.9 ± 1.723 ± 10
    17Basal inferoseptal4.8 ± 1.720 ± 9
    18Basal inferior6.6 ± 1.522 ± 10
    19Basal inferolateral8.5 ± 1.628 ± 13
    20Basal anterolateral9.3 ± 1.626 ± 12
    Average7.8 ± 2.046 ± 20
    • Data are expressed as mean ± SD; n = 64.

    • View popup
    TABLE 3

    Correlation Between Automatic and Visual Motion Scores

    Automatic scoresVisual scoresTotal
    0–12345
    0–11,314606301,383
    2731324272256
    3277599199229
    45111731670
    5236312062
    Total1,42128117091372,000
    • Agreement = 80%; weighted κ = 0.71; SE = 0.02.

    • Boldface type indicates segments with exact agreement.

    • View popup
    TABLE 4

    Correlation Between Automatic and Visual Thickening Scores

    Automatic scoresVisual scoresTotal
    0–123
    0–11,4264831,477
    216320927401
    3113182127
    Total1,6002881122,000
    • Agreement = 86%; weighted κ = 0.68; SE = 0.02.

    • Boldface type indicates segments with exact agreement.

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Journal of Nuclear Medicine
Vol. 42, Issue 11
November 1, 2001
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Quantitative Analysis of Regional Motion and Thickening by Gated Myocardial Perfusion SPECT: Normal Heterogeneity and Criteria for Abnormality
Tali Sharir, Daniel S. Berman, Parker B. Waechter, Joseph Areeda, Paul B. Kavanagh, Jim Gerlach, Xingping Kang, Guido Germano
Journal of Nuclear Medicine Nov 2001, 42 (11) 1630-1638;

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Quantitative Analysis of Regional Motion and Thickening by Gated Myocardial Perfusion SPECT: Normal Heterogeneity and Criteria for Abnormality
Tali Sharir, Daniel S. Berman, Parker B. Waechter, Joseph Areeda, Paul B. Kavanagh, Jim Gerlach, Xingping Kang, Guido Germano
Journal of Nuclear Medicine Nov 2001, 42 (11) 1630-1638;
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