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OtherBASIC SCIENCE INVESTIGATIONS

Biologic Dosimetry of Bone Marrow: Induction of Micronuclei in Reticulocytes After Exposure to 32P and 90Y

Marek Lenarczyk, S. Murty Goddu, Dandamudi V. Rao and Roger W. Howell
Journal of Nuclear Medicine January 2001, 42 (1) 162-169;
Marek Lenarczyk
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S. Murty Goddu
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Dandamudi V. Rao
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Roger W. Howell
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  • FIGURE 1.
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    FIGURE 1.

    Frequency of induction of MnRETs in peripheral blood of mice as function of time after intravenous injection of 32P-orthophosphate. Results are shown for three different injected activities. Error bars represent SEs of mean for two independent experiments.

  • FIGURE 2.
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    FIGURE 2.

    Frequency of induction of MnRETs in peripheral blood of mice as function of time after intravenous injection of 90Y-citrate. Response curves are shown for three different injected activities. Error bars represent SEs of mean for two independent experiments.

  • FIGURE 3.
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    FIGURE 3.

    Frequency of induction of MnRETs in peripheral blood of mice as function of time after initiating irradiation with external γ-rays from 137Cs irradiator. Dose rate was decreased exponentially, with Td of 255 h, which corresponds to Te from femurs of mice that were injected with 32P-orthophosphate. Data points represent mean ± SE of mean of two independent experiments.

  • FIGURE 4.
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    FIGURE 4.

    Frequency of induction of MnRETs in peripheral blood of mice as function of time after initiating irradiation with external γ-rays from 137Cs irradiator. Dose rate was decreased exponentially, with Td of 64 h, which corresponds to Te of radioactivity from the femurs of mice that were injected with 90Y-citrate. Data points represent mean ± SE of mean of two independent experiments.

  • FIGURE 5.
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    FIGURE 5.

    Frequency of induction of MnRETs in peripheral blood of mice as function of AInj of 32P-orthophosphate on third day after administration. Error bars represent SEs of mean for two independent experiments.

  • FIGURE 6.
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    FIGURE 6.

    Frequency of induction of MnRETs in peripheral blood of mice as function of AInj of 90Y-citrate on second day after administration. Error bars represent SEs of mean for two independent experiments.

  • FIGURE 7.
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    FIGURE 7.

    Frequency of induction of MnRETs in peripheral blood of mice as function of initial dose rate from 137Cs–γ-rays on third day after initiating irradiation. External γ-rays were delivered with exponentially decreasing dose rate, with Td of 255 h. Error bars represent SEs of mean for two independent experiments.

  • FIGURE 8.
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    FIGURE 8.

    Frequency of induction of MnRETs in peripheral blood of mice as function of initial dose rate from 137Cs–γ-rays on second day after initiating irradiation. External γ-rays were delivered with exponentially decreasing dose rate, with Td of 64 h. Error bars represent SEs of mean for two independent experiments.

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    TABLE 1.

    Comparison of Half-Times

    Treatment regimenTe* (h)Td (h)TMn (h)
    32P-orthophosphate
     AInj = 642 kBq255—298
     AInj = 1,166 kBq255—288
    90Y-citrate
     AInj = 370 kBq64—94
     AInj = 1,110 kBq64—84
    137Cs–γ-rays
     ro = 1.33 cGy/h—6477
     ro = 2.86 cGy/h—6498
     ro = 0.36 cGy/h—255252
     ro = 1.05 cGy/h—255254
    • ↵* These data are from (9,14).

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Journal of Nuclear Medicine
Vol. 42, Issue 1
January 1, 2001
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Biologic Dosimetry of Bone Marrow: Induction of Micronuclei in Reticulocytes After Exposure to 32P and 90Y
Marek Lenarczyk, S. Murty Goddu, Dandamudi V. Rao, Roger W. Howell
Journal of Nuclear Medicine Jan 2001, 42 (1) 162-169;

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Biologic Dosimetry of Bone Marrow: Induction of Micronuclei in Reticulocytes After Exposure to 32P and 90Y
Marek Lenarczyk, S. Murty Goddu, Dandamudi V. Rao, Roger W. Howell
Journal of Nuclear Medicine Jan 2001, 42 (1) 162-169;
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