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Journal of Nuclear Medicine

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Research ArticleBasic Science Investigations

Clinical Optimization of Pretargeted Radioimmunotherapy with Antibody-Streptavidin Conjugate and 90Y-DOTA-Biotin

Hazel B. Breitz, Paul L. Weiden, Paul L. Beaumier, Donald B. Axworthy, Chris Seiler, Fu-Min Su, Scott Graves, Kyle Bryan and John M. Reno
Journal of Nuclear Medicine January 2000, 41 (1) 131-140;
Hazel B. Breitz
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Paul L. Weiden
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Paul L. Beaumier
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Donald B. Axworthy
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Chris Seiler
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Fu-Min Su
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Scott Graves
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Kyle Bryan
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John M. Reno
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Journal of Nuclear Medicine
Vol. 41, Issue 1
January 1, 2000
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Clinical Optimization of Pretargeted Radioimmunotherapy with Antibody-Streptavidin Conjugate and 90Y-DOTA-Biotin
Hazel B. Breitz, Paul L. Weiden, Paul L. Beaumier, Donald B. Axworthy, Chris Seiler, Fu-Min Su, Scott Graves, Kyle Bryan, John M. Reno
Journal of Nuclear Medicine Jan 2000, 41 (1) 131-140;

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Clinical Optimization of Pretargeted Radioimmunotherapy with Antibody-Streptavidin Conjugate and 90Y-DOTA-Biotin
Hazel B. Breitz, Paul L. Weiden, Paul L. Beaumier, Donald B. Axworthy, Chris Seiler, Fu-Min Su, Scott Graves, Kyle Bryan, John M. Reno
Journal of Nuclear Medicine Jan 2000, 41 (1) 131-140;
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  • Pretargeted {alpha} Emitting Radioimmunotherapy Using 213Bi 1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-Tetraacetic Acid-Biotin
  • Optimizing Bispecific Antibody Pretargeting for Use in Radioimmunotherapy
  • Development of New Multivalent-bispecific Agents for Pretargeting Tumor Localization and Therapy
  • Pharmacokinetics and Dosimetry Studies for Optimization of Anti-Carcinoembryonic Antigen x Anti-Hapten Bispecific Antibody-mediated Pretargeting of Iodine-131-labeled Hapten in a Phase I Radioimmunotherapy Trial
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  • Pretarget radiotherapy with an anti-CD25 antibody-streptavidin fusion protein was effective in therapy of leukemia/lymphoma xenografts
  • Radioimmunotherapy of A431 Xenografted Mice with Pretargeted B3 Antibody-Streptavidin and 90Y-labeled 1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic Acid (DOTA)-Biotin
  • Pretargeting radioimmunotherapy of a murine model of adult T-cell leukemia with the alpha -emitting radionuclide, bismuth 213
  • Targeted Therapy of Cancer with Radiolabeled Antibodies
  • Molecular Advances in Pretargeting Radioimunotherapy with Bispecific Antibodies
  • Cloning and Characterization of Scavidin, a Fusion Protein for the Targeted Delivery of Biotinylated Molecules
  • A 3-Step Pretargeting Strategy to Image Infection
  • In Vivo Biotin Supplementation at a Pharmacologic Dose Decreases Proliferation Rates of Human Peripheral Blood Mononuclear Cells and Cytokine Release
  • The Clearance and Metabolism of Biotin Administered Intravenously to Pigs in Tracer and Physiologic Amounts Is Much More Rapid than Previously Appreciated
  • A Tetravalent Single-chain Antibody-Streptavidin Fusion Protein for Pretargeted Lymphoma Therapy
  • How Far Have We Come with Solid (Nonhematologic) Tumor Radioimmunotherapy?
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