First-in-Human Study of 18F-Labeled PET Tracer for Glutamate AMPA Receptor [18F]K-40: A Derivative of [11C]K-2

Sadamitsu Ichijo; Tetsu Arisawa; Mai Hatano; Waki Nakajima; Tomoyuki Miyazaki; Tsuyoshi Eiro; Yuuki Takada; Ryunosuke Iai; Akane Sano; Masaki Sonoda; Yutaro Takayama; Yuichi Kimura; Takuya Takahashi

doi:10.2967/jnumed.124.269405

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First-in-Human Study of ¹⁸F-Labeled PET Tracer for Glutamate AMPA Receptor [¹⁸F]K-40: A Derivative of [¹¹C]K-2

Sadamitsu Ichijo, Tetsu Arisawa, Mai Hatano, Waki Nakajima, Tomoyuki Miyazaki, Tsuyoshi Eiro, Yuuki Takada, Ryunosuke Iai, Akane Sano, Masaki Sonoda, Yutaro Takayama, Yuichi Kimura and Takuya Takahashi

Journal of Nuclear Medicine May 2025, jnumed.124.269405; DOI: https://doi.org/10.2967/jnumed.124.269405

Sadamitsu Ichijo

1Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan;

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Tetsu Arisawa

1Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan;

2Yokohama City University Graduate School of Medicine, Radioisotope Research Center, Yokohama, Japan;

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Mai Hatano

1Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan;

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Waki Nakajima

1Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan;

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Tomoyuki Miyazaki

1Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan;

3Center for Promotion of Research and Industry–Academic Collaboration, Yokohama City University, Yokohama, Japan;

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Tsuyoshi Eiro

1Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan;

4Department of Psychiatry, Yokohama City University Graduate School of Medicine, Yokohama, Japan;

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Yuuki Takada

1Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan;

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Ryunosuke Iai

1Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan;

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Akane Sano

1Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan;

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Masaki Sonoda

5Department of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan; and

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Yutaro Takayama

5Department of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan; and

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Yuichi Kimura

6Faculty of Informatics, Cyber Informatics Institute, Kindai University, Higashi-Osaka, Japan

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Takuya Takahashi

1Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan;

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Journal of Nuclear Medicine

Vol. 66, Issue 6

June 1, 2025

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First-in-Human Study of ¹⁸F-Labeled PET Tracer for Glutamate AMPA Receptor [¹⁸F]K-40: A Derivative of [¹¹C]K-2

Sadamitsu Ichijo, Tetsu Arisawa, Mai Hatano, Waki Nakajima, Tomoyuki Miyazaki, Tsuyoshi Eiro, Yuuki Takada, Ryunosuke Iai, Akane Sano, Masaki Sonoda, Yutaro Takayama, Yuichi Kimura, Takuya Takahashi

Journal of Nuclear Medicine May 2025, jnumed.124.269405; DOI: 10.2967/jnumed.124.269405

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First-in-Human Study of ¹⁸F-Labeled PET Tracer for Glutamate AMPA Receptor [¹⁸F]K-40: A Derivative of [¹¹C]K-2

Sadamitsu Ichijo, Tetsu Arisawa, Mai Hatano, Waki Nakajima, Tomoyuki Miyazaki, Tsuyoshi Eiro, Yuuki Takada, Ryunosuke Iai, Akane Sano, Masaki Sonoda, Yutaro Takayama, Yuichi Kimura, Takuya Takahashi

Journal of Nuclear Medicine May 2025, jnumed.124.269405; DOI: 10.2967/jnumed.124.269405

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PET
AMPA receptor
neuroimaging
first-in-human study

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First-in-Human Study of ¹⁸F-Labeled PET Tracer for Glutamate AMPA Receptor [¹⁸F]K-40: A Derivative of [¹¹C]K-2

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