Validating the Utility of Supervised Clustering Algorithm for Precise [11C]DPA-713 PET Brain Image Quantification

Youjin Lee; Thanh D. Nguyen; Yong Du; Jennifer M. Coughlin; Sara A. Zein; Nicolas A. Karakatsanis; Sadek Nehmeh; Martin G. Pomper; Susan A. Gauthier; Yeona Kang

doi:10.2967/jnumed.124.268519

Research ArticleClinical Investigation

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Validating the Utility of Supervised Clustering Algorithm for Precise [¹¹C]DPA-713 PET Brain Image Quantification

Youjin Lee, Thanh D. Nguyen, Yong Du, Jennifer M. Coughlin, Sara A. Zein, Nicolas A. Karakatsanis, Sadek Nehmeh, Martin G. Pomper, Susan A. Gauthier and Yeona Kang

Journal of Nuclear Medicine April 2025, jnumed.124.268519; DOI: https://doi.org/10.2967/jnumed.124.268519

Youjin Lee

1Department of Mathematics, Pusan National University, Busan, Republic of Korea;

2Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland;

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Thanh D. Nguyen

3Department of Radiology, Weill Cornell Medicine, New York, New York;

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Yong Du

4Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland;

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Jennifer M. Coughlin

5Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland;

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Sara A. Zein

3Department of Radiology, Weill Cornell Medicine, New York, New York;

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Nicolas A. Karakatsanis

3Department of Radiology, Weill Cornell Medicine, New York, New York;

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Sadek Nehmeh

3Department of Radiology, Weill Cornell Medicine, New York, New York;

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Martin G. Pomper

4Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland;

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Susan A. Gauthier

3Department of Radiology, Weill Cornell Medicine, New York, New York;

6Department of Neurology, Weill Cornell Medical College, New York, New York; and

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Yeona Kang

2Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland;

7Department of Mathematics, Howard University, Washington, DC

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Journal of Nuclear Medicine

Vol. 66, Issue 4

April 1, 2025

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Validating the Utility of Supervised Clustering Algorithm for Precise [¹¹C]DPA-713 PET Brain Image Quantification

Youjin Lee, Thanh D. Nguyen, Yong Du, Jennifer M. Coughlin, Sara A. Zein, Nicolas A. Karakatsanis, Sadek Nehmeh, Martin G. Pomper, Susan A. Gauthier, Yeona Kang

Journal of Nuclear Medicine Apr 2025, jnumed.124.268519; DOI: 10.2967/jnumed.124.268519

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Validating the Utility of Supervised Clustering Algorithm for Precise [¹¹C]DPA-713 PET Brain Image Quantification

Youjin Lee, Thanh D. Nguyen, Yong Du, Jennifer M. Coughlin, Sara A. Zein, Nicolas A. Karakatsanis, Sadek Nehmeh, Martin G. Pomper, Susan A. Gauthier, Yeona Kang

Journal of Nuclear Medicine Apr 2025, jnumed.124.268519; DOI: 10.2967/jnumed.124.268519

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Keywords

PET
[11C]DPA-713
neuroinflammation
multiple sclerosis
supervised clustering algorithm

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