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Research ArticleClinical Investigation

Comparison of [68Ga]Ga-Fibroblast Activation Protein Inhibitor–04 and [18F]FDG PET Imaging for Solitary Fibrous Tumor and Preliminary Application of FAP-Targeted Radiopharmaceutical Therapy

Rongxi Wang, Jiarou Wang, Jialin Xiang, Huimin Sui, Linlin Li, Chenhao Jia, Xingtong Peng, Xiaoyuan Chen, Zhaohui Zhu and Jingjing Zhang
Journal of Nuclear Medicine March 2025, jnumed.124.268258; DOI: https://doi.org/10.2967/jnumed.124.268258
Rongxi Wang
1Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China;
2Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;
3Theranostics Center of Excellence, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;
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Jiarou Wang
1Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China;
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Jialin Xiang
1Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China;
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Huimin Sui
1Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China;
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Linlin Li
1Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China;
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Chenhao Jia
1Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China;
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Xingtong Peng
1Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China;
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Xiaoyuan Chen
2Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;
3Theranostics Center of Excellence, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;
4Nanomedicine Translational Research Program, NUS Center for Nanomedicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;
5Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;
6Department of Chemical and Biomolecular Engineering, College of Design and Engineering, National University of Singapore, Singapore, Singapore;
7Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, Singapore;
8Department of Pharmacy and Pharmaceutical Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore; and
9Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research, Singapore, Singapore
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Zhaohui Zhu
1Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China;
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Jingjing Zhang
2Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;
3Theranostics Center of Excellence, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;
4Nanomedicine Translational Research Program, NUS Center for Nanomedicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;
5Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;
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Article Information

jnumed.124.268258
DOI 
https://doi.org/10.2967/jnumed.124.268258
PubMed 
40049742

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication July 3, 2024
  • Accepted for publication February 3, 2025
  • Published online March 6, 2025.

Article Versions

  • You are currently viewing a previous version of this article (March 6, 2025 - 08:08).
  • View the most recent version of this article
Copyright & Usage 
© 2025 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Rongxi Wang1,2,3,
  2. Jiarou Wang1,
  3. Jialin Xiang1,
  4. Huimin Sui1,
  5. Linlin Li1,
  6. Chenhao Jia1,
  7. Xingtong Peng1,
  8. Xiaoyuan Chen*,2,3,4,5,6,7,8,9,
  9. Zhaohui Zhu*,1 and
  10. Jingjing Zhang*,2,3,4,5
  1. 1Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China;
  2. 2Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;
  3. 3Theranostics Center of Excellence, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;
  4. 4Nanomedicine Translational Research Program, NUS Center for Nanomedicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;
  5. 5Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;
  6. 6Department of Chemical and Biomolecular Engineering, College of Design and Engineering, National University of Singapore, Singapore, Singapore;
  7. 7Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, Singapore;
  8. 8Department of Pharmacy and Pharmaceutical Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore; and
  9. 9Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research, Singapore, Singapore
  1. For correspondence or reprints, contact Jingjing Zhang (j.zhang{at}nus.edu.sg), Zhaohui Zhu (13611093752{at}163.com), or Xiaoyuan Chen (chen.shawn{at}nus.edu.sg).
  1. ↵* Contributed equally to this work.

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Journal of Nuclear Medicine: 66 (5)
Journal of Nuclear Medicine
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May 1, 2025
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Comparison of [68Ga]Ga-Fibroblast Activation Protein Inhibitor–04 and [18F]FDG PET Imaging for Solitary Fibrous Tumor and Preliminary Application of FAP-Targeted Radiopharmaceutical Therapy
Rongxi Wang, Jiarou Wang, Jialin Xiang, Huimin Sui, Linlin Li, Chenhao Jia, Xingtong Peng, Xiaoyuan Chen, Zhaohui Zhu, Jingjing Zhang
Journal of Nuclear Medicine Mar 2025, jnumed.124.268258; DOI: 10.2967/jnumed.124.268258

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Comparison of [68Ga]Ga-Fibroblast Activation Protein Inhibitor–04 and [18F]FDG PET Imaging for Solitary Fibrous Tumor and Preliminary Application of FAP-Targeted Radiopharmaceutical Therapy
Rongxi Wang, Jiarou Wang, Jialin Xiang, Huimin Sui, Linlin Li, Chenhao Jia, Xingtong Peng, Xiaoyuan Chen, Zhaohui Zhu, Jingjing Zhang
Journal of Nuclear Medicine Mar 2025, jnumed.124.268258; DOI: 10.2967/jnumed.124.268258
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Keywords

  • [68Ga]Ga-FAPI-04
  • [18F]FDG
  • solitary fibrous tumor
  • sarcoma
  • [177Lu]Lu-EB-FAPI
  • radiopharmaceutical therapy
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