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Research ArticleClinical Investigation

A Phase I/IIa Clinical Trial to Evaluate Safety and Adrenal Uptake of Para-Chloro-2-[18F]Fluoroethyletomidate in Healthy Volunteers and Patients with Primary Aldosteronism

Daniel Gillett, Russell Senanayake, James MacFarlane, Waiel Bashari, August Palma, Lihua Hu, Ines Harper, Iosif A. Mendichovszky, Gunnar Antoni, Per Hellman, Anders Sundin, Matthew Hird, István Boros, Morris J. Brown, Heok Cheow, Luigi Aloj, Franklin Aigbirhio and Mark Gurnell
Journal of Nuclear Medicine January 2025, jnumed.124.268425; DOI: https://doi.org/10.2967/jnumed.124.268425
Daniel Gillett
1Cambridge Endocrine Molecular Imaging Group, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom;
2Department of Nuclear Medicine, Addenbrooke’s Hospital, Cambridge, United Kingdom;
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Russell Senanayake
1Cambridge Endocrine Molecular Imaging Group, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom;
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James MacFarlane
1Cambridge Endocrine Molecular Imaging Group, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom;
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Waiel Bashari
1Cambridge Endocrine Molecular Imaging Group, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom;
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August Palma
1Cambridge Endocrine Molecular Imaging Group, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom;
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Lihua Hu
1Cambridge Endocrine Molecular Imaging Group, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom;
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Ines Harper
2Department of Nuclear Medicine, Addenbrooke’s Hospital, Cambridge, United Kingdom;
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Iosif A. Mendichovszky
2Department of Nuclear Medicine, Addenbrooke’s Hospital, Cambridge, United Kingdom;
3Department of Radiology, University of Cambridge, Cambridge, United Kingdom;
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Gunnar Antoni
4Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden;
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Per Hellman
5Department of Surgical Sciences, Uppsala University, Uppsala, Sweden;
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Anders Sundin
5Department of Surgical Sciences, Uppsala University, Uppsala, Sweden;
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Matthew Hird
6Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom;
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István Boros
7Radiopharmaceutical Unit, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom; and
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Morris J. Brown
8Department of Endocrinology, Queen Mary University of London, London, United Kingdom
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Heok Cheow
2Department of Nuclear Medicine, Addenbrooke’s Hospital, Cambridge, United Kingdom;
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Luigi Aloj
2Department of Nuclear Medicine, Addenbrooke’s Hospital, Cambridge, United Kingdom;
3Department of Radiology, University of Cambridge, Cambridge, United Kingdom;
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Franklin Aigbirhio
6Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom;
7Radiopharmaceutical Unit, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom; and
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Mark Gurnell
1Cambridge Endocrine Molecular Imaging Group, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom;
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Article Information

jnumed.124.268425
DOI 
https://doi.org/10.2967/jnumed.124.268425
PubMed 
39884776

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication July 17, 2024
  • Accepted for publication December 16, 2024
  • Published online January 30, 2025.

Article Versions

  • You are currently viewing a previous version of this article (January 30, 2025 - 06:58).
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Copyright & Usage 
© 2025 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Daniel Gillett*,1,2,
  2. Russell Senanayake*,1,
  3. James MacFarlane1,
  4. Waiel Bashari1,
  5. August Palma1,
  6. Lihua Hu1,
  7. Ines Harper2,
  8. Iosif A. Mendichovszky2,3,
  9. Gunnar Antoni4,
  10. Per Hellman5,
  11. Anders Sundin5,
  12. Matthew Hird6,
  13. István Boros7,
  14. Morris J. Brown8,
  15. Heok Cheow2,
  16. Luigi Aloj2,3,
  17. Franklin Aigbirhio†,6,7 and
  18. Mark Gurnell†,1
  1. 1Cambridge Endocrine Molecular Imaging Group, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom;
  2. 2Department of Nuclear Medicine, Addenbrooke’s Hospital, Cambridge, United Kingdom;
  3. 3Department of Radiology, University of Cambridge, Cambridge, United Kingdom;
  4. 4Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden;
  5. 5Department of Surgical Sciences, Uppsala University, Uppsala, Sweden;
  6. 6Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom;
  7. 7Radiopharmaceutical Unit, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom; and
  8. 8Department of Endocrinology, Queen Mary University of London, London, United Kingdom
  1. For correspondence or reprints, contact Mark Gurnell (mg299{at}medschl.cam.ac.uk).
  1. ↵* Contributed equally to this work.

  2. ↵† Contributed equally to this work.

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    Emily Goodchild, Xilin Wu, Russell Senanayake, James MacFarlane, Giulia Argentesi, Kate Laycock, Waiel A. Bashari, Claudia P. Cabrera, Samuel M. O’Toole, Jackie Salsbury, Daniela Benu, Yun-Ni Lee, Aldons C.N. Chua, Matthew Matson, Brendan Koo, Laila Parvanta, Nicholas Hilliard, Vasilis Kosmoliaptsis, Alison Marker, Daniel M. Berney, Kiera Drew, Wilson Tan, Roger Foo, Charles A. Mein, Eva Wozniak, Jessica Kearney, Emanuel Savage, Anju Sahdev, Nicholas Bird, Graham Smith, Matthew Hird, Victoria Warnes, Daniel Gillett, Anne Dawnay, Elizabeth Adeyeye, Franklin Aigbirhio, Alasdair McIntosh, Alex McConnachie, J. Kennedy Cruickshank, Heok Cheow, Mark Gurnell, William M. Drake, Morris J. Brown
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  • Adrenal Vein Sampling in Primary Aldosteronism—Is The Gold Standard Losing Its Luster?
    Jaap Deinum, Adina F Turcu
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Journal of Nuclear Medicine: 66 (5)
Journal of Nuclear Medicine
Vol. 66, Issue 5
May 1, 2025
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A Phase I/IIa Clinical Trial to Evaluate Safety and Adrenal Uptake of Para-Chloro-2-[18F]Fluoroethyletomidate in Healthy Volunteers and Patients with Primary Aldosteronism
Daniel Gillett, Russell Senanayake, James MacFarlane, Waiel Bashari, August Palma, Lihua Hu, Ines Harper, Iosif A. Mendichovszky, Gunnar Antoni, Per Hellman, Anders Sundin, Matthew Hird, István Boros, Morris J. Brown, Heok Cheow, Luigi Aloj, Franklin Aigbirhio, Mark Gurnell
Journal of Nuclear Medicine Jan 2025, jnumed.124.268425; DOI: 10.2967/jnumed.124.268425

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A Phase I/IIa Clinical Trial to Evaluate Safety and Adrenal Uptake of Para-Chloro-2-[18F]Fluoroethyletomidate in Healthy Volunteers and Patients with Primary Aldosteronism
Daniel Gillett, Russell Senanayake, James MacFarlane, Waiel Bashari, August Palma, Lihua Hu, Ines Harper, Iosif A. Mendichovszky, Gunnar Antoni, Per Hellman, Anders Sundin, Matthew Hird, István Boros, Morris J. Brown, Heok Cheow, Luigi Aloj, Franklin Aigbirhio, Mark Gurnell
Journal of Nuclear Medicine Jan 2025, jnumed.124.268425; DOI: 10.2967/jnumed.124.268425
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Keywords

  • primary aldosteronism
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  • [18F]CETO
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