Borderline Findings in O-(2-[18F]-Fluoroethyl)-l-Tyrosine PET of Patients with Suspected Glioma Relapse: Role in Clinical Practice

Karl-Josef Langen; Gabriele Stoffels; Christian P. Filss; Martin Kocher; Christoph Lerche; Michael Sabel; Marion Rapp; Hosai Noltemeier; Jan-Michael Werner; Garry Ceccon; Michael M. Wollring; Jurij Rosen; Joachim P. Steinbach; Elke Hattingen; Martin R. Weinzierl; Michael Stoffel; Hans Clusmann; N. Jon Shah; Felix M. Mottaghy; Norbert Galldiks; Philipp Lohmann

doi:10.2967/jnumed.124.268768

Research ArticleClinical Investigation

Borderline Findings in O-(2-[¹⁸F]-Fluoroethyl)-l-Tyrosine PET of Patients with Suspected Glioma Relapse: Role in Clinical Practice

Karl-Josef Langen, Gabriele Stoffels, Christian P. Filss, Martin Kocher, Christoph Lerche, Michael Sabel, Marion Rapp, Hosai Noltemeier, Jan-Michael Werner, Garry Ceccon, Michael M. Wollring, Jurij Rosen, Joachim P. Steinbach, Elke Hattingen, Martin R. Weinzierl, Michael Stoffel, Hans Clusmann, N. Jon Shah, Felix M. Mottaghy, Norbert Galldiks and Philipp Lohmann

Journal of Nuclear Medicine January 2025, jnumed.124.268768; DOI: https://doi.org/10.2967/jnumed.124.268768

Karl-Josef Langen

1Institute of Neuroscience and Medicine (INM-3/INM-4/INM-5/INM-11), Forschungszentrum Jülich, Jülich, Germany;

2Department of Nuclear Medicine, University Hospital RWTH Aachen, Aachen, Germany;

3Center of Integrated Oncology, Aachen Bonn Cologne Duesseldorf, Germany;

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Gabriele Stoffels

1Institute of Neuroscience and Medicine (INM-3/INM-4/INM-5/INM-11), Forschungszentrum Jülich, Jülich, Germany;

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Christian P. Filss

1Institute of Neuroscience and Medicine (INM-3/INM-4/INM-5/INM-11), Forschungszentrum Jülich, Jülich, Germany;

2Department of Nuclear Medicine, University Hospital RWTH Aachen, Aachen, Germany;

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Martin Kocher

1Institute of Neuroscience and Medicine (INM-3/INM-4/INM-5/INM-11), Forschungszentrum Jülich, Jülich, Germany;

4Department of Stereotaxy and Functional Neurosurgery, Center for Neurosurgery, Faculty of Medicine and University Hospital Cologne, Cologne, Germany;

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Christoph Lerche

1Institute of Neuroscience and Medicine (INM-3/INM-4/INM-5/INM-11), Forschungszentrum Jülich, Jülich, Germany;

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Michael Sabel

3Center of Integrated Oncology, Aachen Bonn Cologne Duesseldorf, Germany;

5Department of Neurosurgery, University of Duesseldorf, Duesseldorf, Germany;

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Marion Rapp

3Center of Integrated Oncology, Aachen Bonn Cologne Duesseldorf, Germany;

5Department of Neurosurgery, University of Duesseldorf, Duesseldorf, Germany;

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Hosai Noltemeier

5Department of Neurosurgery, University of Duesseldorf, Duesseldorf, Germany;

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Jan-Michael Werner

6Department of Neurology, Faculty of Medicine and University Hospital Cologne, Cologne, Germany;

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Garry Ceccon

6Department of Neurology, Faculty of Medicine and University Hospital Cologne, Cologne, Germany;

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Michael M. Wollring

6Department of Neurology, Faculty of Medicine and University Hospital Cologne, Cologne, Germany;

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Jurij Rosen

6Department of Neurology, Faculty of Medicine and University Hospital Cologne, Cologne, Germany;

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Joachim P. Steinbach

7University Cancer Center Frankfurt, Goethe University Hospital, Frankfurt am Main, Germany;

8Dr. Senckenberg Institute of Neurooncology, Goethe University Frankfurt, Frankfurt am Main, Germany;

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Elke Hattingen

7University Cancer Center Frankfurt, Goethe University Hospital, Frankfurt am Main, Germany;

9Institute of Neuroradiology, Goethe University Hospital, Frankfurt am Main, Germany;

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Martin R. Weinzierl

10Department of Neurosurgery, Helios Clinics Krefeld, Krefeld, Germany;

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Michael Stoffel

10Department of Neurosurgery, Helios Clinics Krefeld, Krefeld, Germany;

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Hans Clusmann

11Department of Neurosurgery, University Hospital RWTH Aachen, Aachen, Germany;

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N. Jon Shah

1Institute of Neuroscience and Medicine (INM-3/INM-4/INM-5/INM-11), Forschungszentrum Jülich, Jülich, Germany;

12JARA-BRAIN-Translational Medicine, Aachen, Germany;

13Department of Neurology, RWTH Aachen University, Aachen, Germany; and

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Felix M. Mottaghy

2Department of Nuclear Medicine, University Hospital RWTH Aachen, Aachen, Germany;

3Center of Integrated Oncology, Aachen Bonn Cologne Duesseldorf, Germany;

12JARA-BRAIN-Translational Medicine, Aachen, Germany;

14Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, The Netherlands

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Norbert Galldiks

1Institute of Neuroscience and Medicine (INM-3/INM-4/INM-5/INM-11), Forschungszentrum Jülich, Jülich, Germany;

3Center of Integrated Oncology, Aachen Bonn Cologne Duesseldorf, Germany;

6Department of Neurology, Faculty of Medicine and University Hospital Cologne, Cologne, Germany;

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Philipp Lohmann

1Institute of Neuroscience and Medicine (INM-3/INM-4/INM-5/INM-11), Forschungszentrum Jülich, Jülich, Germany;

2Department of Nuclear Medicine, University Hospital RWTH Aachen, Aachen, Germany;

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Journal of Nuclear Medicine

Vol. 66, Issue 3

March 1, 2025

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Borderline Findings in O-(2-[¹⁸F]-Fluoroethyl)-l-Tyrosine PET of Patients with Suspected Glioma Relapse: Role in Clinical Practice

Journal of Nuclear Medicine Jan 2025, jnumed.124.268768; DOI: 10.2967/jnumed.124.268768

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Borderline Findings in O-(2-[¹⁸F]-Fluoroethyl)-l-Tyrosine PET of Patients with Suspected Glioma Relapse: Role in Clinical Practice

Journal of Nuclear Medicine Jan 2025, jnumed.124.268768; DOI: 10.2967/jnumed.124.268768

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Keywords

cerebral glioma
recurrence
treatment-related changes
amino acid PET
FET

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