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Research ArticleTranslational Science Investigation
Open Access

Imaging Demyelinated Axons After Spinal Cord Injuries with PET Tracer [18F]3F4AP

Karla M. Ramos-Torres, Sara Conti, Yu-Peng Zhou, Amal Tiss, Celine Caravagna, Kazue Takahashi, Miao He, Moses Q. Wilks, Sophie Eckl, Yang Sun, Jason Biundo, Kuang Gong, Zhigang He, Clas Linnman and Pedro Brugarolas
Journal of Nuclear Medicine January 2025, jnumed.124.268242; DOI: https://doi.org/10.2967/jnumed.124.268242
Karla M. Ramos-Torres
1Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;
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Sara Conti
2F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts; and
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Yu-Peng Zhou
1Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;
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Amal Tiss
1Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;
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Celine Caravagna
2F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts; and
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Kazue Takahashi
1Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;
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Miao He
2F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts; and
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Moses Q. Wilks
1Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;
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Sophie Eckl
2F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts; and
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Yang Sun
1Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;
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Jason Biundo
2F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts; and
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Kuang Gong
1Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;
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Zhigang He
2F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts; and
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Clas Linnman
3Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, Boston, Massachusetts
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Pedro Brugarolas
1Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;
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Article Information

jnumed.124.268242
DOI 
https://doi.org/10.2967/jnumed.124.268242
PubMed 
39819685

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication June 12, 2024
  • Accepted for publication December 2, 2024
  • Published online January 16, 2025.

Article Versions

  • You are currently viewing a previous version of this article (January 16, 2025 - 12:38).
  • View the most recent version of this article
Copyright & Usage 
© 2025 by the Society of Nuclear Medicine and Molecular Imaging. Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: https://jnm.snmjournals.org/page/permissions.

Author Information

  1. Karla M. Ramos-Torres1,
  2. Sara Conti2,
  3. Yu-Peng Zhou1,
  4. Amal Tiss1,
  5. Celine Caravagna2,
  6. Kazue Takahashi1,
  7. Miao He2,
  8. Moses Q. Wilks1,
  9. Sophie Eckl2,
  10. Yang Sun1,
  11. Jason Biundo2,
  12. Kuang Gong1,
  13. Zhigang He2,
  14. Clas Linnman3 and
  15. Pedro Brugarolas1
  1. 1Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;
  2. 2F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts; and
  3. 3Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, Boston, Massachusetts
  1. For correspondence or reprints, contact Pedro Brugarolas (pbrugarolas{at}mgh.harvard.edu).
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Journal of Nuclear Medicine: 66 (5)
Journal of Nuclear Medicine
Vol. 66, Issue 5
May 1, 2025
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Imaging Demyelinated Axons After Spinal Cord Injuries with PET Tracer [18F]3F4AP
Karla M. Ramos-Torres, Sara Conti, Yu-Peng Zhou, Amal Tiss, Celine Caravagna, Kazue Takahashi, Miao He, Moses Q. Wilks, Sophie Eckl, Yang Sun, Jason Biundo, Kuang Gong, Zhigang He, Clas Linnman, Pedro Brugarolas
Journal of Nuclear Medicine Jan 2025, jnumed.124.268242; DOI: 10.2967/jnumed.124.268242

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Imaging Demyelinated Axons After Spinal Cord Injuries with PET Tracer [18F]3F4AP
Karla M. Ramos-Torres, Sara Conti, Yu-Peng Zhou, Amal Tiss, Celine Caravagna, Kazue Takahashi, Miao He, Moses Q. Wilks, Sophie Eckl, Yang Sun, Jason Biundo, Kuang Gong, Zhigang He, Clas Linnman, Pedro Brugarolas
Journal of Nuclear Medicine Jan 2025, jnumed.124.268242; DOI: 10.2967/jnumed.124.268242
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Keywords

  • spinal cord injury
  • demyelination
  • [18F]3F4AP
  • PET
  • translational study
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