Synthesis of 64Cu-, 55Co-, and 68Ga-Labeled Radiopharmaceuticals Targeting Neurotensin Receptor-1 for Theranostics: Adjusting In Vivo Distribution Using Multiamine Macrocycles

German O. Fonseca Cabrera; Xinrui Ma; Wilson Lin; Tao Zhang; Weiling Zhao; Liqin Pan; Xiaomei Li; Todd E. Barnhart; Eduardo Aluicio-Sarduy; Huaifu Deng; Xuedan Wu; Kadalipura P. Rakesh; Zibo Li; Jonathan W. Engle; Zhanhong Wu

doi:10.2967/jnumed.124.267469

Research ArticleBasic Science Investigation

Synthesis of ⁶⁴Cu-, ⁵⁵Co-, and ⁶⁸Ga-Labeled Radiopharmaceuticals Targeting Neurotensin Receptor-1 for Theranostics: Adjusting In Vivo Distribution Using Multiamine Macrocycles

German O. Fonseca Cabrera, Xinrui Ma, Wilson Lin, Tao Zhang, Weiling Zhao, Liqin Pan, Xiaomei Li, Todd E. Barnhart, Eduardo Aluicio-Sarduy, Huaifu Deng, Xuedan Wu, Kadalipura P. Rakesh, Zibo Li, Jonathan W. Engle and Zhanhong Wu

Journal of Nuclear Medicine June 2024, jnumed.124.267469; DOI: https://doi.org/10.2967/jnumed.124.267469

German O. Fonseca Cabrera

1Biomedical Research Imaging Center, Department of Radiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;

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Xinrui Ma

1Biomedical Research Imaging Center, Department of Radiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;

2Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina;

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Wilson Lin

3Department of Medical Physics, University of Wisconsin, Madison, Wisconsin; and

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Tao Zhang

1Biomedical Research Imaging Center, Department of Radiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;

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Weiling Zhao

1Biomedical Research Imaging Center, Department of Radiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;

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Liqin Pan

1Biomedical Research Imaging Center, Department of Radiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;

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Xiaomei Li

4Accunovo Biotechnologies, Inc., Chapel Hill, North Carolina

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Todd E. Barnhart

3Department of Medical Physics, University of Wisconsin, Madison, Wisconsin; and

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Eduardo Aluicio-Sarduy

3Department of Medical Physics, University of Wisconsin, Madison, Wisconsin; and

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Huaifu Deng

1Biomedical Research Imaging Center, Department of Radiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;

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Xuedan Wu

1Biomedical Research Imaging Center, Department of Radiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;

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Kadalipura P. Rakesh

1Biomedical Research Imaging Center, Department of Radiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;

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Zibo Li

1Biomedical Research Imaging Center, Department of Radiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;

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Jonathan W. Engle

2Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina;

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Zhanhong Wu

1Biomedical Research Imaging Center, Department of Radiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;

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Journal of Nuclear Medicine

Vol. 66, Issue 5

May 1, 2025

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Synthesis of ⁶⁴Cu-, ⁵⁵Co-, and ⁶⁸Ga-Labeled Radiopharmaceuticals Targeting Neurotensin Receptor-1 for Theranostics: Adjusting In Vivo Distribution Using Multiamine Macrocycles

Journal of Nuclear Medicine Jun 2024, jnumed.124.267469; DOI: 10.2967/jnumed.124.267469

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Synthesis of ⁶⁴Cu-, ⁵⁵Co-, and ⁶⁸Ga-Labeled Radiopharmaceuticals Targeting Neurotensin Receptor-1 for Theranostics: Adjusting In Vivo Distribution Using Multiamine Macrocycles

Journal of Nuclear Medicine Jun 2024, jnumed.124.267469; DOI: 10.2967/jnumed.124.267469

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Keywords

radiotheranostic agent
prostate cancer
PET
neurotensin receptor
64Cu
55Co
68Ga

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