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Research ArticleClinical Investigation
Open Access

Examining the Relationship and Prognostic Significance of Cell-Free DNA Levels and the PSMA-Positive Tumor Volume in Men with Prostate Cancer: A Retrospective–Prospective [68Ga]Ga-PSMA-11 PET/CT Study

Kilian Kluge, Holger Einspieler, David Haberl, Clemens Spielvogel, Stefan Stoiber, Chrysoula Vraka, Laszlo Papp, Sabine Wunsch, Gerda Egger, Gero Kramer, Bernhard Grubmüller, Shahrokh Shariat, Marcus Hacker, Lukas Kenner and Alexander Haug
Journal of Nuclear Medicine November 2023, jnumed.123.266158; DOI: https://doi.org/10.2967/jnumed.123.266158
Kilian Kluge
1Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria;
2Christian Doppler Laboratory for Applied Metabolomics, Medical University of Vienna, Vienna, Austria;
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Holger Einspieler
1Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria;
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David Haberl
1Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria;
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Clemens Spielvogel
1Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria;
2Christian Doppler Laboratory for Applied Metabolomics, Medical University of Vienna, Vienna, Austria;
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Stefan Stoiber
2Christian Doppler Laboratory for Applied Metabolomics, Medical University of Vienna, Vienna, Austria;
3Department of Pathology, Medical University of Vienna, Vienna, Austria;
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Chrysoula Vraka
1Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria;
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Laszlo Papp
4Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria;
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Sabine Wunsch
1Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria;
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Gerda Egger
3Department of Pathology, Medical University of Vienna, Vienna, Austria;
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Gero Kramer
5Department of Urology, Medical University of Vienna, Vienna, Austria;
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Bernhard Grubmüller
5Department of Urology, Medical University of Vienna, Vienna, Austria;
6Department of Urology and Andrology, University Hospital Krems, Krems, Austria;
7Karl Landsteiner University of Health Sciences, Krems, Austria;
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Shahrokh Shariat
5Department of Urology, Medical University of Vienna, Vienna, Austria;
6Department of Urology and Andrology, University Hospital Krems, Krems, Austria;
8Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria;
9Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas;
10Division of Urology, Department of Special Surgery, University of Jordan, Amman, Jordan;
11Department of Urology, Second Faculty of Medicine, Charles University, Prague, Czech Republic; and
12Department of Urology, Weill Cornell Medical College, New York, New York
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Marcus Hacker
1Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria;
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Lukas Kenner
2Christian Doppler Laboratory for Applied Metabolomics, Medical University of Vienna, Vienna, Austria;
3Department of Pathology, Medical University of Vienna, Vienna, Austria;
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Alexander Haug
1Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria;
2Christian Doppler Laboratory for Applied Metabolomics, Medical University of Vienna, Vienna, Austria;
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Article Information

jnumed.123.266158
DOI 
https://doi.org/10.2967/jnumed.123.266158
PubMed 
38050125

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication June 13, 2023
  • Revision received September 27, 2023
  • Published online November 30, 2023.

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  • You are currently viewing a previous version of this article (November 30, 2023 - 08:22).
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Copyright & Usage 
© 2024 by the Society of Nuclear Medicine and Molecular Imaging. Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: http://jnm.snmjournals.org/site/misc/permission.xhtml.

Author Information

  1. Kilian Kluge1,2,
  2. Holger Einspieler1,
  3. David Haberl1,
  4. Clemens Spielvogel1,2,
  5. Stefan Stoiber2,3,
  6. Chrysoula Vraka1,
  7. Laszlo Papp4,
  8. Sabine Wunsch1,
  9. Gerda Egger3,
  10. Gero Kramer5,
  11. Bernhard Grubmüller5,6,7,
  12. Shahrokh Shariat5,6,8,9,10,11,12,
  13. Marcus Hacker1,
  14. Lukas Kenner2,3 and
  15. Alexander Haug1,2
  1. 1Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria;
  2. 2Christian Doppler Laboratory for Applied Metabolomics, Medical University of Vienna, Vienna, Austria;
  3. 3Department of Pathology, Medical University of Vienna, Vienna, Austria;
  4. 4Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria;
  5. 5Department of Urology, Medical University of Vienna, Vienna, Austria;
  6. 6Department of Urology and Andrology, University Hospital Krems, Krems, Austria;
  7. 7Karl Landsteiner University of Health Sciences, Krems, Austria;
  8. 8Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria;
  9. 9Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas;
  10. 10Division of Urology, Department of Special Surgery, University of Jordan, Amman, Jordan;
  11. 11Department of Urology, Second Faculty of Medicine, Charles University, Prague, Czech Republic; and
  12. 12Department of Urology, Weill Cornell Medical College, New York, New York
  1. For correspondence or reprints, contact Alexander Haug (alexander.haug{at}meduniwien.ac.at).
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Examining the Relationship and Prognostic Significance of Cell-Free DNA Levels and the PSMA-Positive Tumor Volume in Men with Prostate Cancer: A Retrospective–Prospective [68Ga]Ga-PSMA-11 PET/CT Study
Kilian Kluge, Holger Einspieler, David Haberl, Clemens Spielvogel, Stefan Stoiber, Chrysoula Vraka, Laszlo Papp, Sabine Wunsch, Gerda Egger, Gero Kramer, Bernhard Grubmüller, Shahrokh Shariat, Marcus Hacker, Lukas Kenner, Alexander Haug
Journal of Nuclear Medicine Nov 2023, jnumed.123.266158; DOI: 10.2967/jnumed.123.266158

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Examining the Relationship and Prognostic Significance of Cell-Free DNA Levels and the PSMA-Positive Tumor Volume in Men with Prostate Cancer: A Retrospective–Prospective [68Ga]Ga-PSMA-11 PET/CT Study
Kilian Kluge, Holger Einspieler, David Haberl, Clemens Spielvogel, Stefan Stoiber, Chrysoula Vraka, Laszlo Papp, Sabine Wunsch, Gerda Egger, Gero Kramer, Bernhard Grubmüller, Shahrokh Shariat, Marcus Hacker, Lukas Kenner, Alexander Haug
Journal of Nuclear Medicine Nov 2023, jnumed.123.266158; DOI: 10.2967/jnumed.123.266158
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Keywords

  • liquid biopsy
  • cell-free DNA
  • prostate cancer
  • PSMA
  • PET/CT
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