Biostatistical Estimation of Tau Threshold Hallmarks (BETTH) Algorithm for Human Tau PET Imaging Studies

Alexandra Gogola; Brian J. Lopresti; Dana Tudorascu; Beth Snitz; Davneet Minhas; Vincent Doré; Milos D. Ikonomovic; C. Elizabeth Shaaban; Cristy Matan; Pierrick Bourgeat; N. Scott Mason; Howard Aizenstein; Chester A. Mathis; William E. Klunk; Christopher C. Rowe; Oscar L. Lopez; Ann D. Cohen; Victor L. Villemagne; for the Alzheimer’s Disease Neuroimaging Initiative

doi:10.2967/jnumed.123.265941

Research ArticleClinical Investigation

Biostatistical Estimation of Tau Threshold Hallmarks (BETTH) Algorithm for Human Tau PET Imaging Studies

Alexandra Gogola, Brian J. Lopresti, Dana Tudorascu, Beth Snitz, Davneet Minhas, Vincent Doré, Milos D. Ikonomovic, C. Elizabeth Shaaban, Cristy Matan, Pierrick Bourgeat, N. Scott Mason, Howard Aizenstein, Chester A. Mathis, William E. Klunk, Christopher C. Rowe, Oscar L. Lopez, Ann D. Cohen, Victor L. Villemagne and for the Alzheimer’s Disease Neuroimaging Initiative

Journal of Nuclear Medicine September 2023, jnumed.123.265941; DOI: https://doi.org/10.2967/jnumed.123.265941

Alexandra Gogola

1Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania;

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Brian J. Lopresti

1Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania;

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Dana Tudorascu

2Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania;

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Beth Snitz

3Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania;

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Davneet Minhas

1Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania;

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Vincent Doré

4Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Victoria, Australia;

5Health and Biosecurity, Commonwealth Scientific and Industrial Research Organisation, Melbourne, Victoria, Australia;

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Milos D. Ikonomovic

3Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania;

6Geriatric Research Education and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania; and

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C. Elizabeth Shaaban

7Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania

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Cristy Matan

1Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania;

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Pierrick Bourgeat

5Health and Biosecurity, Commonwealth Scientific and Industrial Research Organisation, Melbourne, Victoria, Australia;

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N. Scott Mason

1Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania;

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Howard Aizenstein

2Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania;

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Chester A. Mathis

1Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania;

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William E. Klunk

2Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania;

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Christopher C. Rowe

4Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Victoria, Australia;

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Oscar L. Lopez

3Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania;

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Ann D. Cohen

2Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania;

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Victor L. Villemagne

2Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania;

4Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Victoria, Australia;

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Journal of Nuclear Medicine

Vol. 66, Issue 5

May 1, 2025

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Biostatistical Estimation of Tau Threshold Hallmarks (BETTH) Algorithm for Human Tau PET Imaging Studies

Alexandra Gogola, Brian J. Lopresti, Dana Tudorascu, Beth Snitz, Davneet Minhas, Vincent Doré, Milos D. Ikonomovic, C. Elizabeth Shaaban, Cristy Matan, Pierrick Bourgeat, N. Scott Mason, Howard Aizenstein, Chester A. Mathis, William E. Klunk, Christopher C. Rowe, Oscar L. Lopez, Ann D. Cohen, Victor L. Villemagne, for the Alzheimer’s Disease Neuroimaging Initiative

Journal of Nuclear Medicine Sep 2023, jnumed.123.265941; DOI: 10.2967/jnumed.123.265941

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Biostatistical Estimation of Tau Threshold Hallmarks (BETTH) Algorithm for Human Tau PET Imaging Studies

Alexandra Gogola, Brian J. Lopresti, Dana Tudorascu, Beth Snitz, Davneet Minhas, Vincent Doré, Milos D. Ikonomovic, C. Elizabeth Shaaban, Cristy Matan, Pierrick Bourgeat, N. Scott Mason, Howard Aizenstein, Chester A. Mathis, William E. Klunk, Christopher C. Rowe, Oscar L. Lopez, Ann D. Cohen, Victor L. Villemagne, for the Alzheimer’s Disease Neuroimaging Initiative

Journal of Nuclear Medicine Sep 2023, jnumed.123.265941; DOI: 10.2967/jnumed.123.265941

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Keywords

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Alzheimer disease
18F-flortaucipir
18F-MK-6240

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