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Research ArticleBasic Science Investigation
Open Access

Evaluation of 134Ce/134La as a PET Imaging Theranostic Pair for 225Ac α-Radiotherapeutics

Kondapa Naidu Bobba, Anil P. Bidkar, Niranjan Meher, Cyril Fong, Anju Wadhwa, Suchi Dhrona, Alex Sorlin, Scott Bidlingmaier, Becka Shuere, Jiang He, David M. Wilson, Bin Liu, Youngho Seo, Henry F. VanBrocklin and Robert R. Flavell
Journal of Nuclear Medicine May 2023, 265355; DOI: https://doi.org/10.2967/jnumed.122.265355
Kondapa Naidu Bobba
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California;
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Anil P. Bidkar
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California;
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Niranjan Meher
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California;
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Cyril Fong
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California;
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Anju Wadhwa
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California;
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Suchi Dhrona
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California;
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Alex Sorlin
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California;
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Scott Bidlingmaier
2Department of Anesthesia, University of California, San Francisco, San Francisco, California;
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Becka Shuere
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California;
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Jiang He
3Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia;
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David M. Wilson
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California;
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Bin Liu
2Department of Anesthesia, University of California, San Francisco, San Francisco, California;
4UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California; and
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Youngho Seo
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California;
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Henry F. VanBrocklin
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California;
4UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California; and
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Robert R. Flavell
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California;
4UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California; and
5Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California
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Article Information

265355
DOI 
https://doi.org/10.2967/jnumed.122.265355
PubMed 
37201957

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication December 21, 2022
  • Revision received March 7, 2023
  • Published online May 18, 2023.

Article Versions

  • You are currently viewing a previous version of this article (May 18, 2023 - 07:28).
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Copyright & Usage 
© 2023 by the Society of Nuclear Medicine and Molecular Imaging. Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: http://jnm.snmjournals.org/site/misc/permission.xhtml.

Author Information

  1. Kondapa Naidu Bobba1,
  2. Anil P. Bidkar1,
  3. Niranjan Meher1,
  4. Cyril Fong1,
  5. Anju Wadhwa1,
  6. Suchi Dhrona1,
  7. Alex Sorlin1,
  8. Scott Bidlingmaier2,
  9. Becka Shuere1,
  10. Jiang He3,
  11. David M. Wilson1,
  12. Bin Liu2,4,
  13. Youngho Seo1,
  14. Henry F. VanBrocklin1,4 and
  15. Robert R. Flavell1,4,5
  1. 1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California;
  2. 2Department of Anesthesia, University of California, San Francisco, San Francisco, California;
  3. 3Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia;
  4. 4UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California; and
  5. 5Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California
  1. For correspondence or reprints, contact Robert R. Flavell (robert.flavell{at}ucsf.edu) or Henry F. VanBrocklin (henry.vanbrocklin{at}ucsf.edu).
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Evaluation of 134Ce/134La as a PET Imaging Theranostic Pair for 225Ac α-Radiotherapeutics
Kondapa Naidu Bobba, Anil P. Bidkar, Niranjan Meher, Cyril Fong, Anju Wadhwa, Suchi Dhrona, Alex Sorlin, Scott Bidlingmaier, Becka Shuere, Jiang He, David M. Wilson, Bin Liu, Youngho Seo, Henry F. VanBrocklin, Robert R. Flavell
Journal of Nuclear Medicine May 2023, 265355; DOI: 10.2967/jnumed.122.265355

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Evaluation of 134Ce/134La as a PET Imaging Theranostic Pair for 225Ac α-Radiotherapeutics
Kondapa Naidu Bobba, Anil P. Bidkar, Niranjan Meher, Cyril Fong, Anju Wadhwa, Suchi Dhrona, Alex Sorlin, Scott Bidlingmaier, Becka Shuere, Jiang He, David M. Wilson, Bin Liu, Youngho Seo, Henry F. VanBrocklin, Robert R. Flavell
Journal of Nuclear Medicine May 2023, 265355; DOI: 10.2967/jnumed.122.265355
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Keywords

  • 134Ce
  • 225Ac
  • targeted α-radiotherapy
  • PET imaging
  • PSMA-617
  • YS5 antibody
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