18F-FDG PET visualizes systemic STING agonist-induced lymphocyte activation in preclinical models

Thuc M. Le; Hailey R. Lee; Evan R. Abt; Khalid Rashid; Amanda L. Creech; Keke Liang; Jing Cui; Arthur Cho; Liu Wei; Amanda Labora; Charlotte Chan; Eric Sanchez; Kriti Kriti; Daniel Karin; Luyi Li; Nanping Wu; Christine Mona; Giuseppe Carlucci; Willy Hugo; Ting-Ting Wu; Timothy R. Donahue; Johannes Czernin; Caius G. Radu

doi:10.2967/jnumed.122.264121

OtherBasic Science (Animal or Phantoms)

¹⁸F-FDG PET visualizes systemic STING agonist-induced lymphocyte activation in preclinical models

Thuc M. Le, Hailey R. Lee, Evan R. Abt, Khalid Rashid, Amanda L. Creech, Keke Liang, Jing Cui, Arthur Cho, Liu Wei, Amanda Labora, Charlotte Chan, Eric Sanchez, Kriti Kriti, Daniel Karin, Luyi Li, Nanping Wu, Christine Mona, Giuseppe Carlucci, Willy Hugo, Ting-Ting Wu, Timothy R. Donahue, Johannes Czernin and Caius G. Radu

Journal of Nuclear Medicine June 2022, jnumed.122.264121; DOI: https://doi.org/10.2967/jnumed.122.264121

Thuc M. Le

1 Department of Molecular and Medical Pharmacology, University of California, United States;

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Hailey R. Lee

1 Department of Molecular and Medical Pharmacology, University of California, United States;

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Evan R. Abt

1 Department of Molecular and Medical Pharmacology, University of California, United States;

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Khalid Rashid

1 Department of Molecular and Medical Pharmacology, University of California, United States;

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Amanda L. Creech

1 Department of Molecular and Medical Pharmacology, University of California, United States;

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Keke Liang

2 Department of Pancreatic and Thyroidal Surgery, Shengjing Hospital, China Medical University, China;

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Jing Cui

3 Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China;

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Arthur Cho

4 Department of Nuclear Medicine, Yonsei University College of Medicine, Korea, Republic of;

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Liu Wei

1 Department of Molecular and Medical Pharmacology, University of California, United States;

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Amanda Labora

5 Department of Surgery, University of California, United States;

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Charlotte Chan

5 Department of Surgery, University of California, United States;

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Eric Sanchez

1 Department of Molecular and Medical Pharmacology, University of California, United States;

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Kriti Kriti

6 Elucidata Corporation, United States;

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Daniel Karin

1 Department of Molecular and Medical Pharmacology, University of California, United States;

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Luyi Li

5 Department of Surgery, University of California, United States;

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Nanping Wu

5 Department of Surgery, University of California, United States;

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Christine Mona

1 Department of Molecular and Medical Pharmacology, University of California, United States;

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Giuseppe Carlucci

1 Department of Molecular and Medical Pharmacology, University of California, United States;

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Willy Hugo

7 Division of Dermatology, Department of Medicine, University of California, United States

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Ting-Ting Wu

1 Department of Molecular and Medical Pharmacology, University of California, United States;

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Timothy R. Donahue

1 Department of Molecular and Medical Pharmacology, University of California, United States;

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Johannes Czernin

1 Department of Molecular and Medical Pharmacology, University of California, United States;

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Caius G. Radu

1 Department of Molecular and Medical Pharmacology, University of California, United States;

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Vol. 66, Issue 5

May 1, 2025

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¹⁸F-FDG PET visualizes systemic STING agonist-induced lymphocyte activation in preclinical models

Journal of Nuclear Medicine Jun 2022, jnumed.122.264121; DOI: 10.2967/jnumed.122.264121

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¹⁸F-FDG PET visualizes systemic STING agonist-induced lymphocyte activation in preclinical models

Journal of Nuclear Medicine Jun 2022, jnumed.122.264121; DOI: 10.2967/jnumed.122.264121

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Keywords

Animal Imaging
Molecular imaging
PET/CT
STING agonists
[18F]FDG PET
immune activation
immunometabolism
lymphocytes

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¹⁸F-FDG PET visualizes systemic STING agonist-induced lymphocyte activation in preclinical models

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