Combination of carriers, with complementary intratumoral microdistributions of delivered α-particles, may realize the promise for Actinium-225 in large solid tumors

Alaina Howe; Omkar Bhatavdekar; Dominick Salerno; Anders Josefsson; Jesus Pacheco-Torres; Zaver M. Bhujwalla; Kathleen L. Gabrielson; George Sgouros; Stavroula Sofou

doi:10.2967/jnumed.121.262992

OtherBasic Science (Animal or Phantoms)

Combination of carriers, with complementary intratumoral microdistributions of delivered α-particles, may realize the promise for Actinium-225 in large solid tumors

Alaina Howe, Omkar Bhatavdekar, Dominick Salerno, Anders Josefsson, Jesus Pacheco-Torres, Zaver M. Bhujwalla, Kathleen L. Gabrielson, George Sgouros and Stavroula Sofou

Journal of Nuclear Medicine November 2021, jnumed.121.262992; DOI: https://doi.org/10.2967/jnumed.121.262992

Alaina Howe

1 Johns Hopkins University - Baltimore, MD, United States;

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Omkar Bhatavdekar

1 Johns Hopkins University - Baltimore, MD, United States;

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Dominick Salerno

2 Johns Hopkins University, United States;

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Anders Josefsson

3 Johns Hopkins University, School of Medicine, United States;

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ORCID record for Anders Josefsson

Jesus Pacheco-Torres

4 Johns Hopkins University, School of medicine, United States

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Zaver M. Bhujwalla

3 Johns Hopkins University, School of Medicine, United States;

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Kathleen L. Gabrielson

3 Johns Hopkins University, School of Medicine, United States;

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George Sgouros

3 Johns Hopkins University, School of Medicine, United States;

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Stavroula Sofou

2 Johns Hopkins University, United States;

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Journal of Nuclear Medicine

Vol. 66, Issue 5

May 1, 2025

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Combination of carriers, with complementary intratumoral microdistributions of delivered α-particles, may realize the promise for Actinium-225 in large solid tumors

Alaina Howe, Omkar Bhatavdekar, Dominick Salerno, Anders Josefsson, Jesus Pacheco-Torres, Zaver M. Bhujwalla, Kathleen L. Gabrielson, George Sgouros, Stavroula Sofou

Journal of Nuclear Medicine Nov 2021, jnumed.121.262992; DOI: 10.2967/jnumed.121.262992

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Combination of carriers, with complementary intratumoral microdistributions of delivered α-particles, may realize the promise for Actinium-225 in large solid tumors

Alaina Howe, Omkar Bhatavdekar, Dominick Salerno, Anders Josefsson, Jesus Pacheco-Torres, Zaver M. Bhujwalla, Kathleen L. Gabrielson, George Sgouros, Stavroula Sofou

Journal of Nuclear Medicine Nov 2021, jnumed.121.262992; DOI: 10.2967/jnumed.121.262992

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Keywords

radiobiology/dosimetry
radionuclide therapy
radiopharmaceuticals
actinium-225
antibodies
liposomes
tumor microdistributions

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Combination of carriers, with complementary intratumoral microdistributions of delivered α-particles, may realize the promise for Actinium-225 in large solid tumors

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