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OtherBasic Science (Animal or Phantoms)

Kinetic Modeling of 18F-(2S,4R)4-Fluoroglutamine in Mouse Models of Breast Cancer to Estimate Glutamine Pool Size as an Indicator of Tumor Glutamine Metabolism

Varsha Viswanath, Rong Zhou, Hsiaoju Lee, Shihong Li, Abigail Cragin, Robert K. Doot, David A. Mankoff and Austin R Pantel
Journal of Nuclear Medicine December 2020, jnumed.120.250977; DOI: https://doi.org/10.2967/jnumed.120.250977
Varsha Viswanath
University of Pennsylvania, United States
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Rong Zhou
University of Pennsylvania, United States
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Hsiaoju Lee
University of Pennsylvania, United States
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Shihong Li
University of Pennsylvania, United States
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Abigail Cragin
University of Pennsylvania, United States
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Robert K. Doot
University of Pennsylvania, United States
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David A. Mankoff
University of Pennsylvania, United States
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Austin R Pantel
University of Pennsylvania, United States
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Article Information

jnumed.120.250977
DOI 
https://doi.org/10.2967/jnumed.120.250977
PubMed 
33277391

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Published online December 4, 2020.

Article Versions

  • You are currently viewing a previous version of this article (December 4, 2020 - 12:52).
  • View the most recent version of this article
Copyright & Usage 
Copyright © 2020 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

Author Information

  1. Varsha Viswanath,
  2. Rong Zhou,
  3. Hsiaoju Lee,
  4. Shihong Li,
  5. Abigail Cragin,
  6. Robert K. Doot,
  7. David A. Mankoff and
  8. Austin R Pantel
  1. University of Pennsylvania, United States
  1. For correspondence or reprints contact: Varsha Viswanath, University of Pennsylvania, Philadelphia, PA 19103, United States. E-mail: varsha.viswanath@pennmedicine.upenn.edu

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Journal of Nuclear Medicine: 66 (5)
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Kinetic Modeling of 18F-(2S,4R)4-Fluoroglutamine in Mouse Models of Breast Cancer to Estimate Glutamine Pool Size as an Indicator of Tumor Glutamine Metabolism
Varsha Viswanath, Rong Zhou, Hsiaoju Lee, Shihong Li, Abigail Cragin, Robert K. Doot, David A. Mankoff, Austin R Pantel
Journal of Nuclear Medicine Dec 2020, jnumed.120.250977; DOI: 10.2967/jnumed.120.250977

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Kinetic Modeling of 18F-(2S,4R)4-Fluoroglutamine in Mouse Models of Breast Cancer to Estimate Glutamine Pool Size as an Indicator of Tumor Glutamine Metabolism
Varsha Viswanath, Rong Zhou, Hsiaoju Lee, Shihong Li, Abigail Cragin, Robert K. Doot, David A. Mankoff, Austin R Pantel
Journal of Nuclear Medicine Dec 2020, jnumed.120.250977; DOI: 10.2967/jnumed.120.250977
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  • 18F-Fluciclovine PET Imaging of Glutaminase Inhibition in Breast Cancer Models
  • First-in-Human PET Imaging and Estimated Radiation Dosimetry of L-[5-11C]-Glutamine in Patients with Metastatic Colorectal Cancer
  • Kinetic and Static Analysis of Poly-(Adenosine Diphosphate-Ribose) Polymerase-1-Targeted 18F-Fluorthanatrace PET Images of Ovarian Cancer
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Keywords

  • Oncology: Breast
  • PET
  • radiotracer tissue kinetics
  • 18F-glutamine
  • Animal Imaging
  • kinetic modeling
  • Numerical simulations
  • Triple negative breast cancer
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