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OtherClinical Investigations (Human)

Non-displaceable binding is a potential confounding factor in 11CPBR28 TSPO PET studies

Gjertrud Louise Laurell, Pontus Plavén-Sigray, Aurelija Jucaite, Andrea Varrone, Kelly P Cosgrove, Claus Svarer, Gitte Moos Knudsen, R Todd Ogden, Francesca Zanderigo, Simon Cervenka, Ansel T Hillmer and Martin Schain
Journal of Nuclear Medicine July 2020, jnumed.120.243717; DOI: https://doi.org/10.2967/jnumed.120.243717
Gjertrud Louise Laurell
1 Rigshospitalet, Denmark;
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Pontus Plavén-Sigray
1 Rigshospitalet, Denmark;
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Aurelija Jucaite
2 Karolinska Institutet, Sweden;
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Andrea Varrone
2 Karolinska Institutet, Sweden;
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Kelly P Cosgrove
3 Yale University School of Medicine and the VACHS, United States;
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Claus Svarer
1 Rigshospitalet, Denmark;
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Gitte Moos Knudsen
1 Rigshospitalet, Denmark;
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R Todd Ogden
4 Columbia University, United States;
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Francesca Zanderigo
4 Columbia University, United States;
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Simon Cervenka
2 Karolinska Institutet, Sweden;
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Ansel T Hillmer
5 Yale University School of Medicine, United States
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Martin Schain
1 Rigshospitalet, Denmark;
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Article Information

jnumed.120.243717
DOI 
https://doi.org/10.2967/jnumed.120.243717
PubMed 
32680926

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Published online July 17, 2020.

Article Versions

  • You are currently viewing a previous version of this article (July 17, 2020 - 13:29).
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Copyright & Usage 
Copyright © 2020 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

Author Information

  1. Gjertrud Louise Laurell1,
  2. Pontus Plavén-Sigray1,
  3. Aurelija Jucaite2,
  4. Andrea Varrone2,
  5. Kelly P Cosgrove3,
  6. Claus Svarer1,
  7. Gitte Moos Knudsen1,
  8. R Todd Ogden4,
  9. Francesca Zanderigo4,
  10. Simon Cervenka2,
  11. Ansel T Hillmer5 and
  12. Martin Schain1
  1. 1 Rigshospitalet, Denmark;
  2. 2 Karolinska Institutet, Sweden;
  3. 3 Yale University School of Medicine and the VACHS, United States;
  4. 4 Columbia University, United States;
  5. 5 Yale University School of Medicine, United States
  1. For correspondence or reprints contact: Gjertrud Louise Laurell, Rigshospitalet, 28 Juliane Maries Vej, Copenhagen 2100, Denmark. E-mail: gjertrud.laurell@nru.dk

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Non-displaceable binding is a potential confounding factor in 11CPBR28 TSPO PET studies
Gjertrud Louise Laurell, Pontus Plavén-Sigray, Aurelija Jucaite, Andrea Varrone, Kelly P Cosgrove, Claus Svarer, Gitte Moos Knudsen, R Todd Ogden, Francesca Zanderigo, Simon Cervenka, Ansel T Hillmer, Martin Schain
Journal of Nuclear Medicine Jul 2020, jnumed.120.243717; DOI: 10.2967/jnumed.120.243717

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Non-displaceable binding is a potential confounding factor in 11CPBR28 TSPO PET studies
Gjertrud Louise Laurell, Pontus Plavén-Sigray, Aurelija Jucaite, Andrea Varrone, Kelly P Cosgrove, Claus Svarer, Gitte Moos Knudsen, R Todd Ogden, Francesca Zanderigo, Simon Cervenka, Ansel T Hillmer, Martin Schain
Journal of Nuclear Medicine Jul 2020, jnumed.120.243717; DOI: 10.2967/jnumed.120.243717
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Keywords

  • Molecular imaging
  • PET
  • radiotracer tissue kinetics
  • [11C]PBR28
  • kinetic modelling
  • Positron Emission Tomography
  • simultaneous estimation
  • translocator protein
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