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Journal of Nuclear Medicine

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OtherClinical Investigations (Human)

Increased P-gp inhibition at the human blood brain barrier can be safely achieved by performing PET during peak plasma concentrations of tariquidar

William Charles Kreisl, Ritwik Bhatia, Cheryl L. Morse, Alicia E. Woock, Sami S. Zoghbi, H. Umesha Shetty, Victor W Pike and Robert B. Innis
Journal of Nuclear Medicine December 2014, jnumed.114.146894; DOI: https://doi.org/10.2967/jnumed.114.146894
William Charles Kreisl
1 1. National Institute of Mental Health, 2) Columbia University Medical Center, United States;
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Ritwik Bhatia
2 National Institute of Mental Health
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Cheryl L. Morse
2 National Institute of Mental Health
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Alicia E. Woock
2 National Institute of Mental Health
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Sami S. Zoghbi
2 National Institute of Mental Health
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H. Umesha Shetty
2 National Institute of Mental Health
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Victor W Pike
2 National Institute of Mental Health
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Robert B. Innis
2 National Institute of Mental Health
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Journal of Nuclear Medicine: 66 (5)
Journal of Nuclear Medicine
Vol. 66, Issue 5
May 1, 2025
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Increased P-gp inhibition at the human blood brain barrier can be safely achieved by performing PET during peak plasma concentrations of tariquidar
William Charles Kreisl, Ritwik Bhatia, Cheryl L. Morse, Alicia E. Woock, Sami S. Zoghbi, H. Umesha Shetty, Victor W Pike, Robert B. Innis
Journal of Nuclear Medicine Dec 2014, jnumed.114.146894; DOI: 10.2967/jnumed.114.146894

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Increased P-gp inhibition at the human blood brain barrier can be safely achieved by performing PET during peak plasma concentrations of tariquidar
William Charles Kreisl, Ritwik Bhatia, Cheryl L. Morse, Alicia E. Woock, Sami S. Zoghbi, H. Umesha Shetty, Victor W Pike, Robert B. Innis
Journal of Nuclear Medicine Dec 2014, jnumed.114.146894; DOI: 10.2967/jnumed.114.146894
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  • A Proof-of-Concept Study to Inhibit ABCG2- and ABCB1-Mediated Efflux Transport at the Human Blood-Brain Barrier
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Keywords

  • Neurology
  • PET
  • research methods
  • N-desmethyl-loperamide
  • P-glycoprotein (P-gp)
  • positron emission tomography (PET)
  • tariquidar
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