Reduced Renal Uptake of Various Radiopharmaceuticals with Sodium Paraaminohippurate Coadministration in a Rat Model

Marian Meckel; Stefanie Ehrenberg; Theresa Schmidt; Philipp Ritt; Margret I. Moré; Ralf Bergmann; Domokos Mathe; Konstantin Zhernosekov

doi:10.2967/jnumed.124.268411

Research ArticleBasic Science Investigation

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Reduced Renal Uptake of Various Radiopharmaceuticals with Sodium Paraaminohippurate Coadministration in a Rat Model

Marian Meckel, Stefanie Ehrenberg, Theresa Schmidt, Philipp Ritt, Margret I. Moré, Ralf Bergmann, Domokos Mathe and Konstantin Zhernosekov

Journal of Nuclear Medicine May 2025, 66 (5) 806-812; DOI: https://doi.org/10.2967/jnumed.124.268411

Marian Meckel

1ITM Medical Isotopes GmbH, Garching, Germany;

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Stefanie Ehrenberg

1ITM Medical Isotopes GmbH, Garching, Germany;

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Theresa Schmidt

1ITM Medical Isotopes GmbH, Garching, Germany;

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Philipp Ritt

2ITM Oncologics GmbH, Garching, Germany;

3Chair for Clinical Nuclear Medicine, Fiedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany;

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Margret I. Moré

2ITM Oncologics GmbH, Garching, Germany;

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Ralf Bergmann

4Department of Biophysics and Radiation Biology, Semmelweis University Budapest, Budapest, Hungary; and

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Domokos Mathe

4Department of Biophysics and Radiation Biology, Semmelweis University Budapest, Budapest, Hungary; and

5CROmed Translational Research Centers Ltd., Budapest, Hungary

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Konstantin Zhernosekov

1ITM Medical Isotopes GmbH, Garching, Germany;

2ITM Oncologics GmbH, Garching, Germany;

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Vol. 66, Issue 5

May 1, 2025

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Reduced Renal Uptake of Various Radiopharmaceuticals with Sodium Paraaminohippurate Coadministration in a Rat Model

Marian Meckel, Stefanie Ehrenberg, Theresa Schmidt, Philipp Ritt, Margret I. Moré, Ralf Bergmann, Domokos Mathe, Konstantin Zhernosekov

Journal of Nuclear Medicine May 2025, 66 (5) 806-812; DOI: 10.2967/jnumed.124.268411

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Reduced Renal Uptake of Various Radiopharmaceuticals with Sodium Paraaminohippurate Coadministration in a Rat Model

Marian Meckel, Stefanie Ehrenberg, Theresa Schmidt, Philipp Ritt, Margret I. Moré, Ralf Bergmann, Domokos Mathe, Konstantin Zhernosekov

Journal of Nuclear Medicine May 2025, 66 (5) 806-812; DOI: 10.2967/jnumed.124.268411

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Keywords

Wistar rats
nephroprotective agent
paraaminohippurate
PAH
[177Lu]Lu-DOTATOC
radiopharmaceutical

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Reduced Renal Uptake of Various Radiopharmaceuticals with Sodium Paraaminohippurate Coadministration in a Rat Model

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