Characterization of Effective Half-Life for Instant Single-Time-Point Dosimetry Using Machine Learning

Carlos Vinícius Gomes; Yizhou Chen; Isabel Rauscher; Song Xue; Andrei Gafita; Jiaxi Hu; Robert Seifert; Lorenzo Mercolli; Julia Brosch-Lenz; Jimin Hong; Marc Ryhiner; Sibylle Ziegler; Ali Afshar-Oromieh; Axel Rominger; Matthias Eiber; Thiago Viana Miranda Lima; Kuangyu Shi

doi:10.2967/jnumed.124.268175

Research ArticleClinical Investigation

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Characterization of Effective Half-Life for Instant Single-Time-Point Dosimetry Using Machine Learning

Carlos Vinícius Gomes, Yizhou Chen, Isabel Rauscher, Song Xue, Andrei Gafita, Jiaxi Hu, Robert Seifert, Lorenzo Mercolli, Julia Brosch-Lenz, Jimin Hong, Marc Ryhiner, Sibylle Ziegler, Ali Afshar-Oromieh, Axel Rominger, Matthias Eiber, Thiago Viana Miranda Lima and Kuangyu Shi

Journal of Nuclear Medicine May 2025, 66 (5) 778-784; DOI: https://doi.org/10.2967/jnumed.124.268175

Carlos Vinícius Gomes

1Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;

2Institute of Radiology and Nuclear Medicine, Lucerne University Teaching and Research Hospital, Lucerne, Switzerland;

3Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland;

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Yizhou Chen

1Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;

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Isabel Rauscher

4Department of Nuclear Medicine, School of Medicine, Technical University Munich, Klinikum Rechts der Isar, Munich, Germany;

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Song Xue

1Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;

5Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Vienna General Hospital, Medical University of Vienna, Vienna, Austria;

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Andrei Gafita

4Department of Nuclear Medicine, School of Medicine, Technical University Munich, Klinikum Rechts der Isar, Munich, Germany;

6Ahmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California;

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Jiaxi Hu

1Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;

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Robert Seifert

1Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;

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Lorenzo Mercolli

1Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;

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Julia Brosch-Lenz

4Department of Nuclear Medicine, School of Medicine, Technical University Munich, Klinikum Rechts der Isar, Munich, Germany;

7Institute of Nuclear Medicine, Glen Burnie, Maryland;

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Jimin Hong

1Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;

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Marc Ryhiner

1Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;

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Sibylle Ziegler

8Department of Nuclear Medicine, Hannover Medical School (MHH), Hannover, Germany;

9Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany; and

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Ali Afshar-Oromieh

1Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;

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Axel Rominger

1Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;

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Matthias Eiber

4Department of Nuclear Medicine, School of Medicine, Technical University Munich, Klinikum Rechts der Isar, Munich, Germany;

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Thiago Viana Miranda Lima

2Institute of Radiology and Nuclear Medicine, Lucerne University Teaching and Research Hospital, Lucerne, Switzerland;

10Faculty of Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland

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Kuangyu Shi

1Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;

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Characterization of Effective Half-Life for Instant Single-Time-Point Dosimetry Using Machine Learning

Journal of Nuclear Medicine May 2025, 66 (5) 778-784; DOI: 10.2967/jnumed.124.268175

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Characterization of Effective Half-Life for Instant Single-Time-Point Dosimetry Using Machine Learning

Journal of Nuclear Medicine May 2025, 66 (5) 778-784; DOI: 10.2967/jnumed.124.268175

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Keywords

radiopharmaceutical therapy
[177Lu]Lu-PSMA I&T
machine learning
single time point
dosimetry

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