Radiolabeling and Preclinical Evaluation of Therapeutic Efficacy of 225Ac-ch806 in Glioblastoma and Colorectal Cancer Xenograft Models

Christian W. Wichmann; Katherine A. Morgan; Zhipeng Cao; Laura D. Osellame; Nancy Guo; Hui Gan; Edward Reilly; Ingrid J.G. Burvenich; Graeme J. O’Keefe; Paul S. Donnelly; Andrew M. Scott

doi:10.2967/jnumed.123.266894

Research ArticleBasic Science Investigation

Radiolabeling and Preclinical Evaluation of Therapeutic Efficacy of ²²⁵Ac-ch806 in Glioblastoma and Colorectal Cancer Xenograft Models

Christian W. Wichmann, Katherine A. Morgan, Zhipeng Cao, Laura D. Osellame, Nancy Guo, Hui Gan, Edward Reilly, Ingrid J.G. Burvenich, Graeme J. O’Keefe, Paul S. Donnelly and Andrew M. Scott

Journal of Nuclear Medicine September 2024, 65 (9) 1456-1462; DOI: https://doi.org/10.2967/jnumed.123.266894

Christian W. Wichmann

1Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia;

2School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia;

3Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Victoria, Australia;

4School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria, Australia;

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Katherine A. Morgan

4School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria, Australia;

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Zhipeng Cao

1Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia;

2School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia;

3Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Victoria, Australia;

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Laura D. Osellame

1Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia;

2School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia;

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Nancy Guo

1Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia;

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Hui Gan

1Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia;

2School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia;

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Edward Reilly

5AbbVie–Oncology Discovery, North Chicago, Illinois; and

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Ingrid J.G. Burvenich

1Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia;

2School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia;

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Graeme J. O’Keefe

3Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Victoria, Australia;

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Paul S. Donnelly

4School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria, Australia;

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Andrew M. Scott

1Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia;

2School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia;

3Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Victoria, Australia;

6Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia

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Vol. 65, Issue 9

September 1, 2024

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Radiolabeling and Preclinical Evaluation of Therapeutic Efficacy of ²²⁵Ac-ch806 in Glioblastoma and Colorectal Cancer Xenograft Models

Christian W. Wichmann, Katherine A. Morgan, Zhipeng Cao, Laura D. Osellame, Nancy Guo, Hui Gan, Edward Reilly, Ingrid J.G. Burvenich, Graeme J. O’Keefe, Paul S. Donnelly, Andrew M. Scott

Journal of Nuclear Medicine Sep 2024, 65 (9) 1456-1462; DOI: 10.2967/jnumed.123.266894

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Radiolabeling and Preclinical Evaluation of Therapeutic Efficacy of ²²⁵Ac-ch806 in Glioblastoma and Colorectal Cancer Xenograft Models

Christian W. Wichmann, Katherine A. Morgan, Zhipeng Cao, Laura D. Osellame, Nancy Guo, Hui Gan, Edward Reilly, Ingrid J.G. Burvenich, Graeme J. O’Keefe, Paul S. Donnelly, Andrew M. Scott

Journal of Nuclear Medicine Sep 2024, 65 (9) 1456-1462; DOI: 10.2967/jnumed.123.266894

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