Diagnostic Performance of [¹⁸F]AlF-Thretide PET/CT in Patients with Newly Diagnosed Prostate Cancer Using Histopathology as Reference Standard

(A) Sequential dynamic maximum-intensity projections of [¹⁸F]AlF-thretide PET/CT derived from patient with primary PCa (arrows). (B–D) Time–activity curves based on dynamic PET/CT scans from 3 patients.

A 63-y-old man with biopsy-proven PCa with prostate-specific antigen level of 12.60 ng/mL at time of [¹⁸F]AlF-thretide PET/CT. (B) Standard images revealed distinct uptake in right peripheral zone (red arrows) (C) Delayed images demonstrated another focus of activity in left peripheral zone (blue arrows). (D) Hematoxylin–eosin staining confirmed bilateral tumors (right peripheral zone, ISUP grade of 2; left peripheral zone, ISUP grade of 1) (top), and immunohistochemical results showed strong PSMA expression (bottom).

(A) [¹⁸F]AlF-thretide PET/CT showed multifocal true-positive tumors (PRIMARY scores of 3, 4, and 4, indicated by red, green, and blue arrows, respectively). There was high imaging–pathology correspondence. (B) [¹⁸F]AlF-thretide PET/CT revealed true-positive tumors (PRIMARY score of 5, red arrow) and false-negative tumor (PRIMARY score of 1, black arrow).